Progress in the study of the correlation between serum uric acid,IGF-1 and osteoporosis
Su Xuan
Jiang Haotian
Yang Yang
Abstract：Osteoporosis(OP)is a systemic bone disease characterized by decreased bonemineral density(BMD)and destruction of bone microarchitecture,which is prone to fracture and seriously affects patients' quality of life.Insulin-like growth factor-1(IGF-1)is a core factor in the regulation of bone metabolism,and its level is regulated by estrogen,growth hormone and other multifactors,which is closely related to the occurrence of primary(POP)and secondary osteoporosis(Sec-OP).Serum uric acid(UA),an endogenous antioxidant,protects BMD by inhibiting oxidative stress,but hyperuricemia may exacerbate bone loss through an inflammatory response.Currently,the relationship between UA and BMD remains controver-sial,and the mechanism of interaction between IGF-1 and UA has not been fully elucidated.This article reviews the association between IGF-1,UA and OP with a view to providing a theoretical basis for early diagnosis and targeted therapy.
Keywords：OsteoporosisInsulin-like growth factor-1Uric acidCorrelation
Publication Date：2025-12-18
Online Publishing Date：2026-01-08(First online date of this platform, not the publication date of the document)
Pages：4( 1524-1526,1531 )