The effects of 3D-DSA-guided neurointerventional thrombectomy on brachial ankle pulse wave velocity and serum Netrin-1 in patients with ischemic stroke
Xiong Liheng
Tao Tingting
Ye Wei
Zhang Jinxing
Abstract：Objective To explore the effects of three-dimensional digital subtraction angiography(3D-DSA)-guided neurointerventional thrombectomy on brachial-ankle pulse wave velocity(ba-PWV)and serum Netrin-1 in patients with ische-mic stroke(IS).Methods From September 2021 to November 2024,totally 180 patients with IS who received treatment in Department of Neurology,Jiangsu Province Hospital/The First Affiliated Hospital with Nanjing Medical University were served as the research subjects and assigned into two groups through the random number table method:thrombolysis group(intravenous thrombolysis)and thrombectomy group(intravenous thrombolysis+3D-DSA-guided neurointerventional throm-bectomy).The vascular recanalization rate,ba-PWV,neurological function,cerebral hemodynamics,serum indicators[neuron specific enolase(NSE),Netrin-1],and adverse reactions were compared.Results The vascular recanalization rate in the thrombectomy group was 94.44％,which was higher than the 83.33％in the thrombolysis group(x2/P=5.625/0.018).After treatment,the thrombectomy group had lower ba-PWV,neurological function score,peripheral resistance(Rv),and NSE(t/P=7.327/＜0.001,16.857/＜0.001,6.630/＜0.001,8.480/＜0.001),and higher Netrin-1 and mean cerebral blood flow(Qm)than the thrombolysis group(t/P=4.905/＜0.001,4.598/＜0.001).There was no prominent difference in adverse reactions between two groups(x2/P=0.669/0.414).Conclusion The 3D-DSA-guided neurointerventional thrombectomy can improve vascular reca-nalization rate,cerebral hemodynamics,reduce the risk of IS recurrence,upregulate Netrin-1 level,inhibit NSE expression,re-duce brain injury,and improve neurological function in patients with IS.
Keywords：Ischemic cerebral strokeThree-dimensional digital subtraction angiographyNeurointerventional throm-bectomyBrachial ankle pulse wave velocityNetrin-1Cerebral hemodynamicsTherapeutic effect
Publication Date：2025-12-18
Online Publishing Date：2026-01-08(First online date of this platform, not the publication date of the document)
Pages：5( 1452-1456 )