The expression of serum Homer1 and DKK3 levels in patients with acute ischemic stroke and their relationship with neurological outcome
Wang Shucun
Wang Jiao
Ren Yao
Zhang Guoxun
Li Zhangxia
Abstract：Objective To investigate the expression of serum homer scaffold protein 1(Homer1)and Dickkopf-3(DKK3)levels in patients with acute ischemic stroke(AIS)and their relationship with neurological outcomes.Methods Ac-cording to the ratio of 2∶1,108 AIS patients(AIS group)and 54 healthy volunteers(healthy control group)were selected from the Department of Neurology,Xianyang Hospital of Yan'an University from January 2022 to October 2024.The AIS group was divided into mild,moderate and severe subgroups according to the National Institutes of Health Stroke Scale(NIHSS)score,and divided into poor subgroup and good subgroup according to the 3-month neurological outcome.The levels of serum Homer1 and DKK3 were detected by enzyme-linked immunosorbent assay,and the correlation between them and NIHSS score was analyzed by Spearman rank correlation.Multivariate logistic regression and receiver operating characteristic analysis were used to analyze the relationship between serum Homer1 and DKK3 levels and neurological outcome in AIS patients and their predictive efficacy.Results Compared with the healthy control group,the serum Homer1 level in the AIS group in-creased and the DKK3 level decreased(t/P=22.391/＜0.001,16.202/＜0.001);Among the 108 AIS patients,31 were mild,42 were moderate,and 35 were severe.The serum Homer1 level in the mild,moderate,and severe subgroups gradually increased,and the DKK3 level gradually decreased(F/P=121.399/＜0.001,174.103/＜0.001);Serum Homerl level was positively correlated with NIHSS score in AIS patients,and DKK3 level was negatively correlated with NIHSS score(rs/P=0.706/＜0.001,-0.745/＜0.001);Compared with the good subgroup,the poor subgroup had higher NIHSS score,larger infarct volume,higher Homer1 and lower DKK3(t/Z/P=4.573/＜0.001,4.520/＜0.001,5.993/＜0.001,6.583/＜0.001);High NIHSS score,large in-farct volume,and high Homer1 were independent risk factors for poor neurological outcomes in AIS patients,and high DKK3 was an independent protective factor[OR(95％CI)=1.088(1.025-1.155),1.392(1.144-1.694),1.307(1.117-1.528),0.892(0.842-0.946)];The areas under the curve of Homer1,DKK3 and their combination in predicting poor neurological outcome in AIS patients were 0.808,0.814 and 0.897,respectively.The combination of the two was superior to their respective predic-tive efficacy(Z/P=2.653/0.008,2.666/0.008).Conclusion The increase of serum Homer1 level and the decrease of DKK3 level in AIS patients are related to the aggravation of the disease and the poor outcome of neurological function.The combina-tion of Homer1 and DKK3 has a higher efficacy in predicting the outcome of neurological function.
Keywords：Acute ischemic strokeHomer scaffold protein 1Dickkopf-3Neurological functional outcomes
Publication Date：2025-12-18
Online Publishing Date：2026-01-08(First online date of this platform, not the publication date of the document)
Pages：6( 1446-1451 )