Correlation between serum LN and Hi-FGF-2 levels and disease severity and prognosis in patients with chronic heart failure complicated by atrial fibrillation

Jia Zhiqing; Du Wala; Liu Yan; Zhang Qi; Zhu Wangliang

doi:10.3969/j.issn.1671-6450.2025.12.006

Abstract：Objective To investigate the correlation of serum laminin(LN)and high molecular weight fibroblast growth factor-2(Hi-FGF-2)levels with the severity and prognosis of patients with chronic heart failure complicated with atrial fibrillation(CHF-AF).Methods A total of 235 patients with CHF-AF admitted to the Department of Cardiology of Inner Mongolia People's Hospital from January 2022 to June 2024 were prospectively enrolled as the CHF-AF group.According to NYHA cardiac function classification,patients were divided into class Ⅰ(n=43),class Ⅱ(n=57),class Ⅲ(n=61),and classⅣ(n=74).Based on 6-month prognosis,patients were categorized into poor prognosis subgroup(n=62)and good prognosis subgroup(n=173).Meanwhile,58 healthy volunteers undergoing physical examination during the same period were included as the control group.Serum LN and Hi-FGF-2 levels were measured by enzyme-linked immunosorbent assay.Spearman cor-relation analysis was used to evaluate the relationship between serum LN,Hi-FGF-2 levels and NYHA classification.Multiva-riate logistic regression was performed to identify risk factors for poor prognosis in CHF-AF patients.Receiver operating char-acteristic(ROC)curve analysis was conducted to assess the predictive value of serum LN and Hi-FGF-2 for poor prognosis.Results Serum LN and Hi-FGF-2 levels were significantly higher in the CHF-AF group than in the control group(t/P=26.273/＜0.001,17.252/＜0.001).Both LN and Hi-FGF-2 levels increased progressively with NYHA class(F/P=42.349/＜0.001,80.620/＜0.001)and were positively correlated with NYHA classification(rs/P=0.670/＜0.001,0.682/＜0.001).The 6-month poor prognosis rate in CHF-AF patients was 26.38％(62/235).The poor prognosis subgroup had higher serum LN and Hi-FGF-2 levels than the good prognosis subgroup(t/P=8.885/＜0.001,6.645/＜0.001).Multivariate logistic regression showed that NYHA class Ⅲ-Ⅳ,elevated NT-proBNP,higher LN,and higher Hi-FGF-2 were independent risk factors for poor prognosis[OR(95％CI)=2.173(1.034-4.568),1.001(1.000-1.001),1.038(1.024-1.053),1.049(1.031-1.067)].The AUCs of LN,Hi-FGF-2,and their combination in predicting poor prognosis were 0.809,0.801,and 0.911,respectively,with the combined model out-performing either marker alone(Z/P=3.803/＜0.001,4.300/＜0.001).Conclusion The levels of serum LN and Hi-FGF-2 in pa-tients with CHF-AF are increased,which are related to the aggravation of the disease and poor prognosis.The combination of the two has a higher predictive efficiency for prognosis.