The clinical efficacy of dapagliflozin in the treatment of non-diabetic acute myocardial infarction and its impact on the TLR4/NF-κB signaling pathway
Li Chao
Tong Ruyou
Li Jun
Sheng Xiaosheng
Abstract：Objective To explore the clinical efficacy of dapagliflozin in the treatment of non-diabetic AMI and its impact on the TLR4/NF-κB signaling pathway.Methods From January 2023 to June 2024,86 non-diabetic AMI patients admitted to Jinhua Municipal People's Hospital were randomly divided into a control group and an observation group,each consisting of 43 cases.The control group received conventional drug therapy,while the observation group was treated with dapagliflozin in addition to the standard treatment,both for six months.Post-treatment cardiac function indicators(LVEF,LVEDD,NT-proBNP),inflammatory factor indicators(TNF-α,IL-6,IL-8),and TLR4/NF-κB signaling pathway-related indicators(TLR4,MyD88,NF-κB mRNA)were analyzed.Additionally,the incidence of adverse drug reactions and major adverse cardiovascular events during treatment was observed.Results After six months of treatment,the observation group had a higher LVEF than the control group(t/P=13.725/＜0.001).The LVEDD,NT-proBNP,TNF-α,IL-6,IL-8,TLR4 mRNA,MyD88 mRNA,and NF-κB mRNA levels were lower in the observation group compared to the control group(t/P=12.732/＜0.001,7.369/0.003,4.659/0.005,5.930/＜0.001,4.169/0.009,11.949/＜0.001,6.594/0.002,8.556/＜0.001),with all differences being statistically significant.During follow-up,the incidence of major adverse cardiovascular events(13.95％,20.93％)and drug adverse reactions(13.95％,18.60％)between the observation group and the control group did not show statistical significance(P＞0.05).Conclusion Dapagliflozin can improve cardiac function in non-diabetic AMI patients,inhibit inflammatory responses,and has good safety.Its mechanism of action may be related to the inhibition of TLR4/NF-κB signaling pathway expression.
Keywords：Acute myocardial infarctionDapagliflozinInflammatory factorsTLR4/NF-κB signaling pathwayTher-apeutic effect
Publication Date：2025-12-18
Online Publishing Date：2026-01-08(First online date of this platform, not the publication date of the document)
Pages：5( 1429-1433 )