Characteristics of serum receptor-interacting protein kinase levels in patients with glucocorticoid-induced osteonecrosis of the femoral head at different clinical stages
Rixiati Paerhati
Aikeremujiang Aerken
Zhai Sheng
Qi Zhenfei
Lyu Qing
Abstract：Objective To investigate the differences in serum receptor-interacting protein kinase(RIPK)levels among patients with steroid-induced osteonecrosis of the femoral head(SONFH)at different clinical stages,and to analyze the correlation between RIPK and the progression of SONFH.Methods A total of 267 patients with SONFH who were treated in the Department of Traumatic Surgery,the Fifth Affiliated Hospital of Xinjiang Medical University from January 2022 to January 2025 were selected as the case group,and 40 healthy subjects who underwent physical examination in the same hospi-tal during the same period were selected as the healthy control group.Patients in the case group were classified into stages Ⅰto Ⅳ according to the Ficat staging criteria.The differences in serum levels of RIPK1,RIPK2,RIPK3,and RIPK4 were com-pared between the two groups and among patients with different stages.Spearman correlation analysis was used to evaluate the correlation between serum levels of each RIPK subtype and the clinical staging of SONFH.Results Among the 267 patients with SONFH,65 cases(24.3％)were in Ficat stage Ⅰ,78 cases(29.2％)in stage Ⅱ,69 cases(25.8％)in stage Ⅲ,and 55 cases(20.7％)in stage Ⅳ.The serum levels of RIPK1,RIPK2,RIPK3,and RIPK4 in the case group were significantly higher than those in the healthy control group(t/P=9.936/＜0.001,10.744/＜0.001,13.996/＜0.001,10.016/＜0.001).With the progres-sion of clinical staging(from stage Ⅰ to Ⅳ),the serum levels of RIPK1,RIPK2,RIPK3,and RIPK4 increased sequentially(F/P=62.221/＜0.001,77.028/＜0.001,58.896/＜0.001,57.522/＜0.001).Spearman correlation analysis showed that serum levels of RIPK1,RIPK2,RIPK3,and RIPK4 in patients with SONFH were significantly positively correlated with Ficat staging(rs=0.611,0.733,0.660,0.704,all P＜0.05).Conclusion The serum levels of RIPK1,RIPK2,RIPK3,and RIPK4 in patients with SONFH are significantly higher than those in the healthy control group,and these RIPK levels gradually increase with the pro-gression of Ficat staging.This suggests that members of the RIPK family are closely related to the severity of SONFH and may be involved in the progression of the disease.
Keywords：Glucocorticoid-induced osteonecrosis of the demoral headReceptor-interacting protein kinaseCorrela-tion
Publication Date：2025-11-18
Online Publishing Date：2025-12-05(First online date of this platform, not the publication date of the document)
Pages：5( 1364-1368 )