Expression of FBXO45 and SLC7A2 in breast cancer patients and their predictive value for postoperative recurrence and metastasis
Wu Fei
Yuan Yuan
He Fan
Du Qiuli
Ruan Jian
Abstract：Objective To investigate the expression of serum F-box protein 45(FBXO45)and solute carrier family 7 member 2(SLC7A2)in patients with breast cancer(BC)and their predictive value for postoperative recurrence and metastasis.Methods From October 2022 to October 2023,106 BC patients who underwent surgical treatment in our hospital were se-lected as the study group.They were classified into a recurrence group(n=29)and a non-recurrence group(n=77)based on the presence or absence of recurrence or metastasis.During the same period,106 patients with benign breast lesions served as the lesion group.ELISA was used to detect serum FBXO45 and SLC7A2 levels.Clinicopathological features and serum mark-er levels were compared between the recurrence and non-recurrence groups.The influencing factors for postoperative recur-rence and metastasis in BC patients were explored.ROC curve analysis was used to evaluate the predictive value of serum FBXO45 and SLC7A2 for postoperative recurrence and metastasis in BC patients.Results Compared with the lesion group,the study group showed higher serum FBXO45(t/P=9.533/＜0.001,7.431/＜0.001)and higher serum SLC7A2(t/P=7.852/＜0.001,7.145/＜0.001).The recurrence group had higher proportions of clinical stage Ⅲ,lymph node metastasis,and vascular invasion than the non-recurrence group(x2/P=12.626/0.002,5.667/0.017,8.022/0.005).Serum FBXO45,SLC7A2,clinical stage,lymph node metastasis,and vascular invasion were identified as influencing factors for postoperative recurrence and me-tastasis in BC patients[OR(95％CI)=1.954(1.052-3.630),1.721(1.125-2.633),2.128(1.080-4.193),2.576(1.133-5.856),0.585(0.387-0.885)].The area under the curve(AUC)values of serum FBXO45,SLC7A2,and their combination in predicting postoperative recurrence and metastasis in BC patients were 0.798,0.801,and 0.907,respectively.The combined prediction was superior to individual predictions(Z combination-FBXO45=2.068,Z combination-SLC7A2=2.127;P=0.039,P=0.033).Conclusion Serum FBXO45 is significantly increased and serum SLC7A2 is significantly decreased in BC patients.Combined detection of both markers has higher predictive value for postoperative recurrence and metastasis in BC patients.
Keywords：Breast cancerF-box protein 45Solute carrier family 7 member 2RecurrenceMetastasisPredictive value
Publication Date：2025-11-18
Online Publishing Date：2025-12-05(First online date of this platform, not the publication date of the document)
Pages：5( 1359-1363 )