The correlation between the expression of LAMTOR1 and RGS20 in lung adenocarcinoma tissues and the clinicopath-ological features and the prognostic value
Li Han
Zhao Wei
Rusitanmu Yasen
Gong Xinji
Hao Yanyan
Kelibiena Tu-erxun
Abstract：Objective To investigate the relationship between the expression of late endosomal/lysosomal adaptor,MAPK and MTOR activator 1(LAMTOR1),regulator of G-protein signaling 20(RGS20)and clinicopathological features and prognosis in advanced lung adenocarcinoma.Methods The clinical data of 144 patients with NSCLC admitted to the Depart-ment of Respiratory Medicine of the First Affiliated Hospital of Xinjiang Medical University from January 2020 to January 2022 were collected.The expressions of LAMTOR1 mRNA,RGS20 mRNA and protein were detected by qPCR and immuno-histochemistry.Kaplan-Meier survival analysis and Cox proportional hazard regression model were used to evaluate the effect of LAMTOR1 and RGS20 expression on patient prognosis.Results The expressions of LAMTOR1 and RGS20 mRNA in lung adenocarcinoma tissues were(2.34±0.56)and(2.63±0.67),which were higher than those in adjacent tissues(0.84±0.26)and(0.74±0.16)(t=29.154,32.925,all P＜0.001).The positive rate of LAMTOR1 in cancer tissues was 70.83％(102/144),which was higher than that in adjacent tissues 5.56％(8/144)(x2=129.968,P＜0.001);the positive rate of RGS20 in cancer tissues was 63.89％(96/144),which was higher than that in adjacent tissues 6.94％(10/144)(x2=110.411,P＜0.001).The positive rates of LAMTOR1 and RGS20 were higher in patients with TNM stage Ⅲ A than in those with TNM stage Ⅰ-Ⅱ,and higher in patients with lymph node metastasis than in those without lymph node metastasis(x2=10.980,6.534,13.333,10.800;P=0.001,0.011,＜0.001,0.001).TNM stage ⅢA,lymph node metastasis,LAMTOR1 positive and RGS20 positive were risk factors for poor prognosis in patients with lung adenocarcinoma[HR(95％CI)=1.344(1.099-1.645),1.305(1.074-1.584),1.363(1.046-1.776),1.354(1.087-1.686)].Conclusion LAMTOR1 and RGS20 are highly expressed in lung adenocarcinoma,which is associated with poor clinicopathological features and can serve as potential prognostic bio-markers.
Keywords：Lung adenocarcinomaLate endosome/lysosome adapter protein 1Regulator of G-protein signaling 20Prognosis
Publication Date：2025-11-18
Online Publishing Date：2025-12-05(First online date of this platform, not the publication date of the document)
Pages：6( 1302-1307 )