The expression and clinical significance of CXCL10 and eHSP72 in peripheral blood of patients with acute respiratory failure
He Ruifeng
Pang Richeng
Zheng Yanchuang
Li Jun
Abstract：Objective To investigate the relationship between peripheral blood CXC chemokine ligand 10(CXCL10),extracellular heat shock protein 72(eHSP72),and the condition and prognosis of patients with acute respiratory failure(ARF).Methods A total of 359 patients with ARF admitted to the Department of Emergency Medicine of Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine/Zhuhai Hospital Affiliated to Southern Medical University from February 2020 to June 2024 were selected.According to the oxygenation index(OI),they were divided into a mild group(201-300 mmHg,102 cases),a moderate group(101-200 mmHg,157 cases),and a severe group(≤100 mmHg,93 cases).The levels of CXCL10 and eHSP72 in peripheral blood were detected.Deaths of ARF patients within 28 days of hospitaliza-tion were recorded,and patients were categorized into a death group and a survival group.Risk factors affecting death within 28 days and the predictive value of CXCL10 and eHSP72 for mortality were analyzed.Results The levels of CXCL10 and eHSP72 in peripheral blood of ARF patients were higher in the severe group than in the moderate group,and higher in the moderate group than in the mild group(F/P=371.739/＜0.001、629.200/＜0.001).Among the 359 patients,106 died and 253 survived.The levels of CXCL10 and eHSP72 in the death group were higher than those in the survival group(t/P=23.237/＜0.001,22.232/＜0.001).Multivariate logistic regression analysis showed that older age,severe ARF,high CXCL10 level,and high eHSP72 level were risk factors for death within 28 days of hospitalization[OR(95％CI)=3.762(1.668-8.486),2.640(1.249-5.583),2.201(1.218-3.979),1.864(1.149-3.026)].The AUCs of CXCL10,eHSP72,and their combination in predicting 28-day mortality were 0.731,0.733,and 0.890,respectively.The AUC of the combination was higher than that of CXCL10 or eHSP72 alone(Z=5.404,5.032,both P＜0.001).Conclusion The levels of CXCL10 and eHSP72 in peripheral blood of ARF patients are significantly increased and are associated with disease severity and poor prognosis.The combination of CXCL10 and eHSP72 improves predictive value for the prognosis of ARF patients.
Keywords：Acute respiratory failureCXC chemokine ligand-10extracellular 72 kDa-heat shock proteinSeverity of illnessPrognosisPredictive value
Publication Date：2025-11-18
Online Publishing Date：2025-12-05(First online date of this platform, not the publication date of the document)
Pages：6( 1292-1296,1307 )