Correlation between glucose and lipid metabolism and serum uric acid levels in type 2 diabetes patients and diabetes retinopathy

Mao Xiaoting; Wen Wen; Li Dongwei

doi:10.3969/j.issn.1671-6450.2025.10.013

Abstract：Objective To observe the relationship between diabetic retinopathy(DR),glucose and lipid metabolism and serum uric acid(SUA)level in patients with type 2 diabetes(T2DM).Methods Ninety-seven patients with type 2 diabe-tes who were admitted to the ophthalmology department of Changsha Third Hospital from September 2021 to September 2022 were selected and divided into non DR group(n=42)and DR group(n=55)according to the presence or absence of DR.Clinical data and serum glucose metabolism indicators[fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS)],lipid metabolism indicators[total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cho-lesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],and serum uric acid(SUA)levels were compared between the two groups.Logistic regression was used to analyze the risk factors for DR in T2DM patients,The predictive value of bio-chemical indicators on the occurrence of DR in T2DM patients was analyzed by subject performance characteristic curve(ROC).Results The course of DM and serum levels of FPG,HbA1c,TC,TG,LDL-C,and SUA in DR group were higher than those in NDR group(t/P=3.784/＜0.001,3.830/＜0.001,4.790/＜0.001,2.912/0.005,3.544/＜0.001,2.168/0.033,and 2.429/0.018).There was no significant difference in serum FINS,SUA levels between the two groups(P＞0.05).Logistic regression analysis showed that long duration of DM,high HbA1c,high TG,and high SUA were risk factors for DR in T2DM patients[OR(95％CI)=1.111(1.021-1.208),2.722(1.182-6.272),1.034(1.019-1.048),3.014(1.278-7.1 1),P＜0.05].The ROC curve analysis showed that the course of DM and the area under the curve for predicting DR by serum HbA1c,TG,and SUA were 0.740,0.767,0.721,and 0.693,respectively.The predictive value of serum HbA1c was higher than other indicators(Z=1.372,1.075,1.499,and 1.268,all P＜0.001).Conclusion DR lesions in T2DM patients are closely related to the course of DM,HbA1c,TG,and SUA levels,and have good predictive value for the occurrence of DR.