The diagnostic value of serum MIP-1 α and PTX3 for patients with cirrhotic ascites complicated with spontaneous bac-terial peritonitis
Feng Meiping
Liao Pengqiang
Xiao Dijuan
You Ting
Abstract：Objective To explore the diagnostic value of serum macrophage inflammatory protein-1α(MIP-1α)and pentraxin 3(PTX3)in patients with cirrhotic ascites complicated with spontaneous bacterial peritonitis(SBP).Methods From August 2019 to December 2024,126 patients with cirrhotic ascites diagnosed and treated in the Department of Gastroenterolo-gy,Chengdu Seventh People's Hospital were enrolled.According to the occurrence of SBP,the patients were divided into an SBP group(n=37)and a non-SBP group(n=89).Serum MIP-1α and PTX3 levels were measured by ELISA.Multivariate lo-gistic regression analysis was used to identify influencing factors for cirrhotic ascites complicated with SBP.The diagnostic value of serum MIP-1α and PTX3 was evaluated using ROC curve analysis.Results The levels of serum MIP-1α,PTX3,and the percentage of polymorphonuclear cells in ascites in the SBP group were significantly higher than those in the non-SBP group(t/P=8.111,8.108/＜0.001).High MIP-1α,high PTX3,and a high percentage of polymorphonuclear cells in ascites were identified as independent risk factors for cirrhotic ascites complicated with SBP[OR(95％ CI)=1.095(1.049-1.143),2.265(1.530-3.352),1.543(1.020-2.333)].The AUC values of serum MIP-1α,PTX3,and their combination for diagnosing cir-rhotic ascites complicated with SBP were 0.885,0.884,and 0.965,respectively.The combined diagnostic value was superior to that of either biomarker alone(Z=2.804,2.880,P=0.005,0.004).Conclusion Serum MIP-1α and PTX3 levels are elevated in patients with cirrhotic ascites complicated with SBP.The combination of the two biomarkers demonstrates good diagnostic efficacy for this condition.
Keywords：Cirrhotic ascitesSpontaneous bacterial peritonitisMacrophage inflammatory protein-1αPentraxin 3Diagnosis
Publication Date：2025-10-18
Online Publishing Date：2025-11-10(First online date of this platform, not the publication date of the document)
Pages：5( 1205-1209 )