Study on the relationship between H.pylori infection and serum NF-κB,G-17,IGF-1 in elderly patients with chronic gastritis

Guo Jiantang; Liu Minghe; Mo Chen; Zhang Yongqing; Zhao Jing; Xu Li

doi:10.3969/j.issn.1671-6450.2025.10.009

Abstract：Objective To investigate the relationship between Helicobacter pylori(Hp)infection and serum nuclear factor kappa B(NF-κB),gastrin-17(G-17),and insulin-like growth factor-1(IGF-1)in elderly patients with chronic gastritis(CG).Methods A total of 120 elderly CG patients admitted to the Third Medical Center of Chinese PLA General Hospital from January to December 2024 were enrolled and divided into an Hp-infected group and an uninfected group based on Hp infection status.General patient information was collected,and serum levels of NF-κB,G-17,and IGF-1 were measured and compared between the two groups upon admission.Logistic regression analysis was used to analyze the correlation between serum NF-κB,G-17,and IGF-1 levels and Hp infection in elderly CG patients.Receiver operating characteristic(ROC)curves were plotted to evaluate the diagnostic value of serum NF-κB,G-17,and IGF-1 levels for Hp infection.Results Among the 120 elderly CG patients who underwent 13C urea breath testing,77(64.17％)were positive(infected group)and 43(35.83％)were negative(uninfected group).Serum interleukin-6(IL-6)and C-reactive protein(CRP)levels in the infected group were higher than those in the uninfected group(t=6.944,6.154,both P＜0.05).No significant differences were observed in other baseline characteristics such as gender and age between the two groups(P＞0.05).The infected group showed higher serum NF-κB levels but lower G-17 and IGF-1 levels compared to the uninfected group(t=7.967,8.118,5.392,all P＜0.05).Logistic regression analysis indicated that high serum G-17 and IGF-1 levels were protective factors against Hp infection(OR=0.813,0.725;P=0.002,0.010),while high NF-κB,IL-6,and CRP levels were risk factors(OR=2.282,2.278,4.375;P=0.002,0.035,0.010).ROC analysis showed that serum NF-κB,G-17,and IGF-1 levels,both individually and in combination,had diagnostic value for Hp infection,with AUC values of 0.887,0.794,and 0.711,respectively.Combined detection further improved diag-nostic performance(AUC=0.902).Conclusion Hp infection in elderly CG patients is associated with serum NF-κB,G-17,and IGF-1 levels.Individual and combined detection of these serum markers demonstrates certain diagnostic value for Hp in-fection.