The predictive value of serum HIF-1α,NLR,and CAR for the prognosis of patients undergoing thoracoscopic radical resection for lung cancer
Zhang Yukun
Zou Zongyan
Zhang Yunzeng
Zhang Mu
Zhang Bo
Abstract：Objective To explore the predictive value of serum hypoxia-inducible factor-1α(HIF-1α),neutrophil-to-lymphocyte ratio(NLR),and C-reactive protein-to-albumin ratio(CAR)for the prognosis of patients undergoing thoracoscopic radical resection for lung cancer.Methods Eighty lung cancer patients who underwent thoracoscopic radical resection at Tai'an Central Hospital Affiliated to Qingdao University from January 2022 to December 2023 were selected.Preoperative serum HIF-1α,NLR,and CAR levels were measured in all patients,and postoperative follow-up was conducted for one year to as-sess prognosis.Serum levels of HIF-1α,NLR,and CAR were compared between patients with different prognostic outcomes.Logistic regression analysis was used to investigate the relationship between these biomarkers and prognosis,and receiver op-erating characteristic(ROC)curves were plotted to evaluate their predictive value.Results Among the 80 patients,19(23.75％)had poor prognosis and 61(76.25％)had good prognosis after one year of follow-up.Patients in the poor prognosis group had higher tumor staging and elevated serum levels of HIF-1α,NLR,and CAR compared to the good prognosis group(x2/t/P=2.699/0.007、8.254/＜0.001、13.383/＜0.001、8.815/＜0.001).Logistic regression analysis showed that elevated serum HIF-1α,NLR,and CAR levels were risk factors for poor prognosis[OR(95％CI)=1.716(1.132-2.600)、8.591(2.256-32.715)、3.188(2.525-5.016)].ROC curve analysis revealed that the AUC values of serum HIF-1α,NLR,and CAR for predicting prognosis were all greater than 0.70,indicating predictive value.Combined detection of these biomarkers further improved pre-dictive accuracy(AUC＞0.90).Optimal cutoff values were 41.175 ng/L for HIF-1α,3.895 for NLR,and 0.525 for CAR.Con-clusion Serum HIF-1α,NLR,and CAR levels are associated with prognosis in patients undergoing thoracoscopic radical re-section for lung cancer and demonstrate high predictive value.These biomarkers may serve as important indicators for postop-erative prognosis evaluation.
Keywords：Thoracoscopic radical resection for lung cancerHypoxia-inducible factor-1αNeutrophil-to-lymphocyte ratioC-reactive protein-to-albumin ratioPrognosisPredictive value
Publication Date：2025-10-18
Online Publishing Date：2025-11-10(First online date of this platform, not the publication date of the document)
Pages：5( 1173-1177 )