Expression of serum Claudin-5 and BTP in patients with severe acute pancreatitis complicated by acute kidney injury and the correlation with disease severity
Zhang Meng
Zhang Pengfei
Xu Huaili
Yang Qi
Chen Mengnan
Abstract：Objective To investigate the expression of serum Claudin-5 and β-trace protein(BTP)in patients with severe acute pancreatitis(SAP)complicated with acute kidney injury(AKI)and its correlation with the severity of the dis-ease.Methods A total of 135 SAP patients admitted to the Department of Gastroenterology,Affiliated Xidian Group Hospital of Shaanxi University of Traditional Chinese Medicine from January 2019 to August 2024 were selected.According to whether AKI was combined,they were divided into AKI group and non-AKI group.According to the degree of illness,they were divided into stage 1 SAP combined with AKI group,stage 2 SAP combined with AKI group,and stage 3 SAP combined with AKI group.The levels of serum Claudin-5 and BTP were detected by enzyme-linked immunosorbent assay.The relation-ship between serum Claudin-5,BTP and SAP combined with AKI was analyzed by multivariate Logistic regression analysis.ROC curve was used to analyze the predictive efficiency of serum Claudin-5 and BTP.Results The incidence of AKI in 135 patients with SAP was 44.44％(60/135).Compared with the non-AKI group,the serum levels of Claudin-5 and BTP in the AKI group were increased(t/P=7.486/＜0.001,8.502/＜0.001);The levels of serum Claudin-5 and BTP in stage 1 SAP com-bined with AKI group,stage 2 SAP combined with AKI group and stage 3 SAP combined with AKI group increased in turn(F/P=36.526/＜0.001,21.304/＜0.001).High APACHE Ⅱ score,high serum creatinine,high Claudin-5 and high BTP were in-dependent risk factors for SAP complicated with AKI[OR(95％CI)=3.375(1.123-10.147),1.025(1.010-1.041),1.001(1.000-1.001),1.320(1.130-1.542)];The area under the curve of serum Claudin-5,BTP levels and the combination of the two in pre-dicting SAP with AKI were 0.772,0.784 and 0.873,respectively.The combination of the two was greater than the AUC predic-ted by serum Claudin-5 and BTP levels alone(Z/P=2.992/0.004,3.071/0.003).Conclusion The increase of serum Claudin-5 and BTP levels is related to the occurrence and severity of SAP combined with AKI.The combination of serum Claudin-5 and BTP levels has a high predictive efficiency for SAP combined with AKI.
Keywords：Severe acute pancreatitisAcute kidney injuryClaudin-5β-trace proteinDisease severity
Publication Date：2025-09-18
Online Publishing Date：2025-10-11(First online date of this platform, not the publication date of the document)
Pages：6( 1063-1068 )