The expression of SPP1,MTSS1,SLC7A11 in tissues of non-small cell lung cancer patients and their relationship with pathological parameters and prognosis
Luo Honglan
Liu Kai
Tong Kai
Pan Lijun
Zhou Dong
Chen Yun-shang
Abstract：Objective To investigate the relationship between the expression of secreted phosphoprotein 1(SPP1),metastasis suppressor 1(MTSS1),and solute carrier family 7 member 11(SLC7A11)in non-small cell lung cancer(NSCLC)tissues and the clinical pathological characteristics and prognosis of patients.Methods A total of 204 NSCLC patients admit-ted to the Department of Oncology of Huanggang Central Hospital from July 2019 to June 2021 were selected as the study ob-jects.The expression of SPP1,MTSS1 and SLC7A11 in cancer tissues and adjacent tissues were detected by immunohisto-chemistry.According to the death situation within 3 years after operation,the patients were divided into death group(n=50)and survival group(n=143).Multivariate Cox regression was used to analyze the prognostic factors of NSCLC.Kaplan-Meier curve was used to analyze the relationship between the expression of SPP1,MTSS1 and SLC7A11 and the prognosis of NSCLC.Results The positive expression rates of SPP1 and SLC7A11 in cancer tissues were significantly higher than those in paracancer tissues,and the positive expression rates of MTSS1 were significantly lower than that in paracancer tissues(x2/P=90.362/＜0.001,100.885/＜0.001,102.073/＜0.001).Among the positive SPP1 expression in NSCLC patients,the percentage of patients with tumor diameter≥5 cm,TNM staging in 35 years,lymph node metastasis and history of smoking was higher(x2/P=5.408/0.020,10.636/＜0.001,6.838/＜0.001,10.352/＜0.001).At the same time,the proportion of these patients in SLC7A11 positive expression was also higher(x2=6.965,7.638,10.597,16.657,P＜0.001),while in MTSS1 positive expres-sion,The proportion of patients with TNM stage Ⅰ to Ⅱ,no lymph node metastasis and no smoking history was higher(x2=9.681,10.611,7.187,P＜0.001).Compared with the survival group,the proportion of smoking history and occupational exposure,TNM stage Ⅲ and lymph node metastasis in the death group was significantly higher(x2/P=7.501/＜0.001,4.205/0.040,12.861/＜0.001,10.907/＜0.001).The survival rate of SPP1 and SLC7A11 positive patients in the death group was lower than that of the survival group,while the survival rate of MTSS1 positive patients in the survival group was higher than that of the death group(x2/P=11.273/＜0.001,11.490/＜0.001,7.603/0.006).Multivariate Cox regression results showed that TNM stage Ⅲ,lymph node metastasis,positive SPP1,positive SLC7A11 and smoking history were all risk factors for poor progno-sis ofNSCLC.Positive MTSS1 was a protective factor for poor prognosis of NSCLC[HR(95％CI)=2.369(1.623-3.458),1.843(1.308-2.597),2.014(1.396-2.906),1.986(1.420-2.777),2.259(1.370-3.724),0.856(0.754-0.972)].The three-year overall survival rate ofNSCLC patients with SPP1 and SLC7A11 positive expression was lower than that of SPP1 and SLC7A11 negative expression(Log Rank x2/P=9.988/0.002,10.608/0.001),respectively.The three-year overall survival rate of patients with positive expression of MTSS1 was higher than that with negative expression of MTSS1(Log Rank x2/P=7.884/0.005).Conclusion SPP1 and SLC7A11 have a high positive expression rate in NSCLC tissues,while MTSS1 has a low positive expression rate in NSCLC tissues.The expression of these three proteins is closely related to the pathological fea-tures and prognosis of NSCLC.
Keywords：Non-small cell lung cancerPhosphoprotein 1Metastasis suppressor 1Solute carrier family 7 member 11Prognosis
Publication Date：2025-09-18
Online Publishing Date：2025-10-11(First online date of this platform, not the publication date of the document)
Pages：7( 1056-1062 )