Correlation between serum circANKRD36 and sRAGE levels and prognosis in patients with sepsis-associated acute re-spiratory distress syndrome
Huan Jianbo
Wang Junwei
Liu Qiushi
Li Congcong
Abstract：Objective To investigate the correlation between serum circANKRD36 and soluble receptor for advanced glycation end products(sRAGE)levels and prognosis in patients with sepsis-associated acute respiratory distress syndrome(ARDS).Methods A total of 92 sepsis patients admitted to the General Hospital of the Northern Theater Command of the Chinese People's Liberation Army from February 2024 to December 2024 were selected.According to the Sepsis-3.0 criteria and Berlin definition,patients were divided into a non-ARDS group(n=44)and an ARDS group(n=48).Based on prognosis,patients with sepsis-associated ARDS were further divided into a survival subgroup(n=28)and a death subgroup(n=20).Re-al-time quantitative polymerase chain reaction(qRT-PCR)was used to detect serum circANKRD36 levels,and enzyme-linked immunosorbent assay(ELISA)was used to measure sRAGE levels.The Kaplan-Meier method was used to analyze differences in 28-day survival.Multivariate Cox regression analysis was employed to identify factors influencing prognosis and death in patients with sepsis-associated ARDS.Results Serum circANKRD36 and sRAGE levels in the ARDS group were higher than those in the non-ARDS group(t/P=2.318/＜0.001,3.743/＜0.001).Survival analysis showed that the mortality rate in the ARDS group was higher than that in the non-ARDS group(x2/P=7.453/0.006).In the death subgroup,PaO2/FiO2 was lower than that in the survival subgroup,while Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,Sequential Or-gan Failure Assessment(SOFA)score,and levels of C-reactive protein(CRP),procalcitonin(PCT),circANKRD36,and sRAGE were higher(t/P=5.670/＜0.001,5.539/＜0.001,5.201/＜0.001,9.605/＜0.001,5.360/＜0.001,10.973/＜0.001,8.834/＜0.001).Multivariate Cox regression analysis indicated that high APACHE Ⅱ score,high SOFA score,high CRP,high PCT,high circANKRD36,and high sRAGE were independent risk factors for poor prognosis in sepsis-associated ARDS patients[HR(95％CI)=1.371(1.199-1.579),1.401(1.201-1.583),1.023(1.013-1.034),1.304(1.149-1.481),1.466(1.278-2.467),1.315(1.266-1.547)],while high PaO2/FiO2 was an independent protective factor[HR(95％CI)=0.975(0.963-0.987)].Conclusions Serum circANKRD36 and sRAGE levels are significantly associated with the 28-day prognosis of sepsis-associated ARDS patients.Abnormally elevated levels of serum circANKRD36 and sRAGE indicate a relatively high risk of death.These bio-markers may serve as potential indicators for evaluating prognosis in sepsis-associated ARDS,and dynamic monitoring could provide important reference for early clinical intervention and individualized treatment strategies.
Keywords：SepsisAcute respiratory distress syndromecircANKRD36Soluble receptor for advanced glycation end productsPrognosis
Publication Date：2025-09-18
Online Publishing Date：2025-10-11(First online date of this platform, not the publication date of the document)
Pages：6( 1050-1055 )