Serum ORM and MFG-E8 as novel biomarkers for severity stratification in aneurysmal subarachnoid hemorrhage
Liu Xu
Jiang Boyi
Li Fang
Guan Furen
He Ruifeng
Abstract：Objective To evaluate serum orosomucoid(ORM)and milk fat globule-EGF-8(MFG-E8)in aSAH severity assessment.Methods According to 1∶1,50 patients with mild,moderate and severe aSAH(aSAH group)were selected from the Emergency Internal Medicine of Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to August 2024,and 150 healthy volunteers were selected as healthy control group.Serum ORM and MFG-E8 levels were detected by enzyme-linked immunosorbent assay;Spearman rank correlation analysis was used to analyze the correlation between serum ORM,MFG-E8 levels and Hunt-Hess grade in patients with aSAH;The relationship between serum ORM,MFG-E8 levels and the severity of aSAH patients was analyzed by ordinal multivariate Logistic regres-sion analysis;ROC curve was used to analyze the energy efficiency of serum ORM and MFG-E8 levels in evaluating the se-verity of aSAH patients.Results Compared with the healthy control group,the serum ORM level in the aSAH group in-creased and the MFG-E8 level decreased(t/P=40.777/＜0.001,177.515/＜0.001).The serum ORM levels in the mild subgroup,the moderate subgroup and the severe subgroup increased in turn,and the MFG-E8 levels decreased in turn(F/P=81.031/＜0.001,96.356/＜0.001);the Hunt-Hess grade of aSAH patients was positively correlated with serum ORM level and negatively correlated with MFG-E8 level(rs/P=0.647/＜0.001,0.655/＜0.001);high ORM was an independent risk factor for aggravation of aSAH,and high MFG-E8 was an independent protective factor[OR(95％CI)=1.007(1.002-1.012),0.291(0.110-0.773)];the area under the curve of serum ORM,MFG-E8 levels and the combination of the two in evaluating the severity of aSAH pa-tients were 0.806,0.820 and 0.897,respectively.The AUC of the combination of the two was greater than that of serum ORM and MFG-E8 levels alone(Z/P=1.928/0.004,1.659/0.006).Conclusion ORM/MFG-E8 are promising biomarkers for aSAH triage and monitoring.
Keywords：Aneurysmal subarachnoid hemorrhageOrosomucoidMilk fat globule-EGF-8Disease severity
Publication Date：2025-09-18
Online Publishing Date：2025-10-11(First online date of this platform, not the publication date of the document)
Pages：6( 1045-1049,1055 )