Cardiac electrophysiological balance index(iCEB)predicts major adverse cardiovascular events after drug-coated balloon angioplasty in elderly CAD patients
Jing Yongli
Zhu Huimin
Li Dongcheng
Zheng Kai
Ma Jun
Abstract：Objective To assess iCEB's predictive value for post-procedural MACE.Methods A retrospective study was conducted on 256 elderly patients with coronary heart disease who underwent drug coated balloon angioplasty at Huai'an First Hospital affiliated with Nanjing Medical University from April 2021 to February 2023.The patients were divided into MACE group(n=37)and non-MACE group(n=219)based on whether MACE occurred one year after surgery.Collect baseline data,preoperative,intraoperative,and postoperative data from patients.Multivariate Logistic regression analysis of the influencing factors of postoperative MACE,and ROC curve analysis of the predictive value of iCEB for post-operative MACE.Results The proportion of Lp(a),iCEB,and moderate to severe coronary artery calcification in the MACE group was higher than that in the non-MACE group(x2/t/P=8.127/＜0.001,57.239/＜0.001,21.241/＜0.001),while the LCX,collateral vessel proportion,QT,and QRS in the MACE group were lower than those in the non-MACE group(x2/t/P=4.775/0.029,4.700/0.030,22.450/＜0.001,7.625/＜0.001).There was no statistically significant difference in other clinical data between the two groups(P＞0.05);The results of logistic regression analysis showed that LCX[OR=0.347,95％CI 0.130-0.929]and collateral vessels[OR=0.433,95％CI0.200-0.937]were non risk factors for postoperative MACE,while mod-erate to severe coronary artery calcification[OR=2.979,95％CI 1.464-6.061]and iCEB[OR=6.018,95％CI 3.551-10.199]were risk factors for postoperative MACE(P＜0.05);The ROC curve analysis results showed that the AUC of moder-ate to severe coronary artery calcification,iCEB,and their combined prediction of postoperative MACE were 0.745,0.789,and 0.887,respectively.The combined detection efficiency of the two was better than that of each indicator detected separately(Z=3.200,2.958,P＜0.001 for all).Conclusion iCEB is a novel electrophysiological marker for post-DCB risk stratification in elderly CAD.
Keywords：Coronary artery diseaseDrug-coated balloonElectrophysiological balance indexMajor adverse cardio-vascular eventsElderly
Publication Date：2025-08-18
Online Publishing Date：2025-09-01(First online date of this platform, not the publication date of the document)
Pages：6( 927-932 )