Research progress of dental pulp stem cell transplantation for the treatment of spinal cord injury
Sun Yunkai
Tao Yun
Xie Hongru
Zhang Qin
Abstract：Spinal cord injury(SCI)is a prevalent and serious neurological disorder that usually results in motor and sensory dysfunction below the plane of injury,placing a heavy burden on patients and the healthcare system.Currently,due to the lack of clarity in the study of the pathophysiological mechanisms of SCI and the difficulty in repairing and regenerating damaged neural tissues,the effectiveness of conventional treatment options for recovery after spinal cord injury is very limited.In recent years,stem cell therapy has attracted widespread attention as a promising therapeutic avenue.Dental pulp stem cells(DPSCs)are an ideal cell source for SCI repair due to their easy accessibility,ease of minimally invasive extraction,and strong neurogenic differentiation ability.It has been shown that DPSCs can differentiate into neural cells to promote SCI repair in ani-mal models.The article provides an overview of DPSCs and the mechanism of action of DPSCs in the treatment of SCI,and focuses on a series of promising therapeutic modalities such as stem cell injection,combined tissue engineering scaffold trans-plantation,and combined exosome therapy in the repair of SCI,with the aim of providing a theoretical basis for the clinical treatment of SCI.
Keywords：Spinal cord injuryDental pulp stem cellsStem cell transplantationScaffold for tissue engineeringExosomes
Publication Date：2025-07-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 880-884 )