The predictive value of serum SMAD4 and NLRP3 for visual prognosis in patients with central retinal vein occlusion
Tian Jing
Ren Wanna
Peng Caixia
Huang Songjian
Sun Yilan
Abstract：Objective To explore the predictive value of serum SMAD4 and NLRP3 for visual prognosis in CRVO patients.Methods This study included 232 CRVO patients(CRVO group)and 100 healthy subjects(control group)from Lanzhou University Second Hospital Eye Clinic from November 2021 to November 2023.All CRVO patients were treated with anti-VEGF intravitreal injections and followed up for 12 months.Based on their best corrected visual acuity(BCVA)changes,they were divided into good-prognosis(165 cases)and poor-prognosis(67 cases)subgroups.Serum SMAD4 and NLRP3 levels were measured by ELISA.Multivariate Logistic regression analysis was used to identify risk factors for poor visual prognosis.ROC curves assessed the predictive value of SMAD4 and NLRP3 for poor visual prognosis.Results Serum SMAD4 and NLRP3 levels were higher in the CRVO group than in the control group(t/P=23.536/0.000,16.918/＜0.001)and higher in the poor-prognosis subgroup than in the good-prognosis subgroup(t/P=9.614/＜0.001,8.864/＜0.001).Multivariate analysis showed high initial BCVA,persistent macular edema,ischemic type,high SMAD4,and high NLRP3 were independent risk factors for poor prognosis[OR(95％CI)=1.685(1.143-2.484),1.772(1.193-2.633),2.061(1.241-3.424),2.325(1.359-3.978),2.149(1.291-3.577)].The AUCs for predicting poor prognosis were 0.853 for SMAD4,0.849 for NLRP3,and 0.932 for the combination,which was better than either alone(Z/P=2.191/0.028,2.470/0.014).Conclusion Serum SMAD4 and NLRP3 levels were elevated in CRVO patients.Their combination showed high predictive efficiency for visual prognosis.
Keywords：Central retinal vein occlusionMothers against DPP homolog 4NOD like receptor thermal protein do-main associated protein 3Prognosis
Publication Date：2025-07-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 855-859 )