The expression and clinical significance of serum Tenascin-C and Midkine in patients with sepsis complicated with myocardial injury

Wu Dong; Guo Xiaowang; Jia Jia; Zhang Ji; Gu Chunyu

doi:10.3969/j.issn.1671-6450.2025.07.002

Abstract：Objective To investigate the expression and clinical significance of serum Tenascin-C and Midkine in pa-tients with sepsis complicated with myocardial injury(MI).Methods A total of 108 patients with sepsis(sepsis group)and 54 healthy volunteers(healthy control group)admitted to the Department of Emergency Medicine of Shaanxi Provincial People's Hospital from January 2019 to December 2024 were selected.Sepsis patients were divided into MI subgroup and non-MI sub-group according to whether they were complicated with MI.The levels of serum Tenascin-C and Midkine were detected by enzyme-linked immunosorbent assay;Multivariate unconditional Logistic regression analysis was used to analyze the factors of sepsis complicated with MI;ROC curve was used to analyze the predictive value of serum Tenascin-C,Midkine levels and other influencing indicators for sepsis complicated with MI.Results Compared with the healthy control group,the levels of serum Tenascin-C and Midkine in the sepsis group were increased(t=13.460,13.414,all P＜0.001);the incidence of MI in pa-tients with sepsis was 46.30％(50/108);Compared with the non-MI subgroup,the levels of serum Tenascin-C and Midkine in the MI subgroup were increased(t=5.783,5.410,P＜0.001).Sequential organ failure assessment(SOFA)score,creatine ki-nase isoenzyme(CK-MB),N-terminal pro-brain natriuretic peptide,Tenascin-C and Midkine were independent risk factors for sepsis complicated with MI[OR(95％CI)=1.169(1.015-1.348),1.685(1.247-2.277),1.003(1.001-1.004),1.342(1.134-1.589),1.616(1.194-2.186)];the areas under the curve of Tenascin-C,Midkine and their combination in predicting sepsis complicated with MI were 0.780,0.774 and 0.874,respectively,the combination of the two was superior to their respective predictive effi-cacy(Z/P=2.601/＜0.001,2.598/＜0.001).Conclusion The increase of serum Tenascin-C and Midkine levels is related to sepsis complicated with MI,and the combination of the two has a high predictive value for sepsis complicated with MI.