Efficacy and safety of Yiqi Huoxue therapy combined with conventional western medicine in the treatment of elderly patients with heart failure:A Meta-analysis
Zhang Xiyu
Zhuo Jianfeng
Qiu Sijie
Zhong Yan
Abstract：Objective To systematically evaluate the clinical efficacy and safety of Yiqi Huoxue therapy combined with conventional western medicine in the treatment of heart failure in the elderly through systematic review and Meta-analy-sis.Methods The original clinical literature related to the treatment of senile heart failure with Yiqi Huoxue therapy com-bined with conventional western medicine was searched by computer.The database was selected from commonly used Chinese and English databases,including China National Knowledge Infrastructure(CNKI),China Biology Medicine Disc(CBM),Wanfang Literature Data platform,VIP journal database platform.English databases included PubMed,Embase and The Co-chraneLibrary.The literature retrieval period was from January 1,2015 to December 1,2020.The latest version of Revman 5.4 software was used to conduct statistical meta-analysis of the relevant data of the included studies.Results A total of 21 RCTS were included,involving 2070 patients(1033 in the control group and 1037 in the experimental group).The results of Meta-analysis showed that The efficacy of cardiac function in the experimental group was significantly higher than that in the control group,and the difference was statistically significant[MD=4.11,95％CI(2.90,5.82),P＜0.00001].LVEF in the experi-mental group was significantly higher than that in the control group[MD=5.41,95％CI(4.18,6.64),P＜0.01],the 6MWD of the experimental group was significantly higher than that of the control group[MfD=64.61,95％CI(49.39,79.83),P＜0.01].NT-proBNP in the experimental group was significantly lower than that in the control group,and the difference was statistical-ly significant[MD=-119.07,95％CI(-148.56,-89.58);LVEDD in the experimental group was significantly lower than that in the control group,the difference was statistically significant[MD=-2.41,95％CI(-4.43,-0.39),P＜0.01].Conclusion Yiqi Huoxue therapy combined with conventional western medicine is safe and effective in the treatment of heart failure in the elderly.However,due to the small number of included studies and the general quality of the studies,high-quality,large-sam-ple,randomized,double-blind trials are needed to confirm it in the future.
Keywords：Heart failureYiqi Huoxue therapyClinical efficacyAdverse reactionsMeta analysisEdlerly
Publication Date：2025-06-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 742-748 )