The relationship between parameters of transvaginal ultrasound and serum VEGF,HIF-1 α level and endometrial re-ceptivity in patients with PCOS
Zhao Fangyuan
Zou Hong
Shi Simao
Xu Fang
Abstract：Objective To investigate the relationship between transvaginal ultrasonography parameters,serum vascular endothelial growth factor(VEGF),hypoxia-inducible factor-1α(HIF-1 α)and endometrial receptivity in patients with polycystic ovary syndrome(PCOS).Methods From April 2019 to December 2021,the Department of Gynecology of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine diagnosed and treated 120 PCOS patients.According to the results of endometrial pinocytosis,42 patients were divided into good receptive group and 78 patients into poor receptive group.Compare the general data,transvaginal ultrasound parameters and serum VEGF,HIF-1 between the two groups α Level,Pearson method to analyze ultrasonic parameters and serum VEGF,HIF-1 α.Logistic regression analysis was used to analyze the risk factors of endometrial receptivity impairment.Results There was no significant difference in age,body mass and body mass index(BMI)between the two groups(P＞0.05).The proportion of patients with hyperandrogenism and hyperinsulinemia in the poor receptive group was higher than that in the good receptive group(x2/P=12.897/＜0.001、5.500/0.019).The mean number of pinocytotic processes,endometrial thickness,endometrial volume and serum VEGF,HIF-1α in patients with poor receptivity were lower than those in the well tolerated group(t=13.804,9.021,15.004,11.453,11.671,P＜0.001),and the resistance index(RI)and pulsatility index(PI)of uterine spiral artery were higher than those in the well tolerated group(t=4.198,8.008,P＜0.001).Endometrial pinocytosis,endometrial thickness,endometrial volume and serum VEGF,HIF-1α in patients with PCOS were positive correlation(VEGF:r/P=0.364/0.007,0.562/＜0.001,0.482/0.011;HIF-1 α:r/P=0.405/0.014,0.409/0.017,0.597/＜0.001),RI and PI of uterus,serum VEGF and HIF-1α were negative correlation(VEGF:r/P=-0.631/0.002,-0.593/0.007;HIF-1 α:r/P=-0.689/0.001、-0.571/0.009).Hyperandrogenism,hyperinsulinemia,low en-dometrial thickness,low endometrial volume,high RI,high PI,low serum VEGF and HIF-1 α were risk factors for poor endo-metrial receptivity in PCOS patients[OR(95％CI)=1.361(1.115-1.607)、1.294(1.017-1.571)、1.852(1.324-2.380)、2.586(1.714-3.458)、1.763(1.203-2.320)、1.608(1.182-2.034)、1.526(1.056-1.996)、1.267(0.571-1.963)].Conclusion Transvaginal ultrasound parameters and serum VEGF,HIF-1α in patients with PCOS is related and is a risk factor for patients with poor endometrial receptivity,which can effectively evaluate patients' endometrial receptivity.
Keywords：Polycystic ovary syndromeEndometrial receptivityTransvaginal ultrasoundVascular endothelial growth factorHypoxia-inducible factor 1αCorrelation
Publication Date：2025-06-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 678-682 )