The predictive efficacy of serum TAX1BP1 and ETS2 levels on ventricular remodeling and poor prognosis in patients with heart failure
Li Yao
Han Suxia
Wu Jingjing
Zhang Kangjian
Gao Suli
Abstract：Objective To investigate the levels of serum tax1 binding protein 1(TAX1BP1)and E26 transformation specific 2(ETS2)in patients with heart failure(HF)and their predictive efficacy for ventricular remodeling(VR)and poor prognosis.Methods From January 2021 to July 2023,165 patients with HF admitted to the Department of Cardiology,Shanghai Pudong New Area People's Hospital were selected as the HF group,and 85 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.HF patients were divided into poor prognosis subgroup(53 cases)and good prognosis subgroup(112 cases)according to the 1-year prognosis.VR indexes[left ventricular posterior wall thickness(LVPWT),left ventricular end-diastolic diameter(LVEDD),end-diastolic interventricular septum thickness(IVST),left ventricular mass index(LVMI)]were measured by echocardiography,and serum TAX1BP1 and ETS2 levels were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was used to analyze the corre-lation between serum TAX1BP1,ETS2 levels and VR indexes in HF patients.Multivariate unconditional Logistic regression a-nalysis and ROC curve were used to analyze the relationship between serum TAX1BP1 and ETS2 levels and the prognosis of HF patients and their predictive efficacy.Results Compared with the control group,LVPWT,LVEDD,IVST,LVMI and ser-um TAX1BP1,ETS2 levels were increased in the HF group(t/P=24.786/＜0.001,15.123/＜0.001,24.411/＜0.001,19.466/＜0.001,15.581/＜0.001,17.897/＜0.001);Serum TAX1BP1 and ETS2 levels were positively correlated with LVPWT,LVEDD,IVST and LVMI in HF patients(r/P=0.646/＜0.001,0.658/＜0.001,0.649/＜0.001,0.679/＜0.001,0.676/＜0.001,0.634/＜0.001,0.642/＜0.001,0.681/＜0.001).The 1-year poor prognosis rate of 165 HF patients was 32.12％(53/165).Compared with the good prognosis subgroup,the serum levels of TAX1BP1 and ETS2 in the poor prognosis subgroup were increased(t/P=6.805/＜0.001,6.721/＜0.001).NYHA cardiac function≥grade Ⅲ,high NT-proBNP,high LVPWT,high LVEDD,high IVST,high LVMI,high TAX1BP1 and high ETS2 were independent risk factors for poor prognosis in HF patients,high LVEF was a protective factor for poor prognosis in HF patients[OR(95％CI)=6.832(1.623-28.762),1.001(1.000-1.001),2.362(1.205-4.629),1.340(1.109-1.618),2.343(1.262-4.349),1.073(1.007-1.142),1.117(1.014-1.231),1.774(1.296-2.428),0.812(0.712-0.927)];the area under the curve of serum TAX1BP1,ETS2 levels and the combination of the two in predicting the poor prognosis of HF patients were 0.790,0.783,and 0.865,respectively.The combination of the two was greater than the AUC predicted by serum TAX1BP1 and ETS2 levels alone(Z/P=2.000/0.046,2.412/0.016).Conclusion The levels of serum TAX1BP1 and ETS2 in HF patients are increased,which are closely related to the aggravation of VR and poor prognosis,and the combination of ser-um TAX1BP1 and ETS2 levels has a high predictive efficiency for the poor prognosis of HF patients.
Keywords：Heart failureTAX1 binding protein 1E26 transformation-specific 2Ventricular remodelingPoor prognosis
Publication Date：2025-06-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 667-672 )