The relationship between systemic immune inflammation index,ambulatory arterial stiffness index and left ventricular hypertrophy in elderly patients with essential hypertension

Liu Chuan; Ma Lina; Cao Ruojin; Zhang Zhongying; Song Yu; Li Yun

doi:10.3969/j.issn.1671-6450.2025.06.003

Abstract：Objective To investigate the relationship between systemic immune-inflammation index(SII)and ambu-latory arterial stiffness index(AASI)and left ventricular hypertrophy(LVH)in elderly patients with essential hypertension.Methods A total of 101 elderly patients with essential hypertension admitted to the Geriatric Medicine Department of Xuan-wu Hospital,Capital Medical University from January 2022 to December 2023 were selected and divided into LVH group(n=35)and non-LVH group(n=66)according to whether LVH occurred.Baseline data,indicators of the first laboratory ex-amination and echocardiographic characteristics of the patients at admission were collected.Multiple Logistic regression analy-sis was conducted to analyze the influencing factors of LVH in elderly patients with essential hypertension,and ROC curve was used to analyze the predictive value of SII and AASI in elderly patients with essential hypertension.Results Compared with LVH group,LVEDD,LVESD,LVM and LVMI in non-LVH group were decreased(t/P=5.633/＜0.001,2.249/0.027,8.289/＜0.001,11.493/＜0.001),and there was no significant difference in LVEF between the two groups(P＞0.05).Compared with LVH group,the levels of SII and AASI in non-LVH group were decreased(t/P=13.824/＜0.001,8.290/＜0.001).The lev-els of SII and AASI were higher than those of LVEDD(r/P=0.456/＜0.001,0.523/＜0.001),LVESD(r/P=0.287/0.019,0.345/0.003)and LVM(r/P=0.563/＜0.001,0.612/＜0.001),respectively There was positive correlation between SII and LVEF(r/P=0.621/＜0.001,0.689/＜0.001),and negative correlation between SII and LVEF(r/P=-0.156/0.165,-0.211/0.047),but no sig-nificant correlation between SII and LVEF(P＞0.05).High SII,high AASI,high LVEDD and high LVM are all independent influencing factors for LVH in elderly patients with essential hypertension[OR(95％CI)=1.136(1.068-1.208),1.174(1.025-4.697),1.425(1.215-1.670),1.039(1.024-1.055)];The AUC of AASI,SII and their combination in predicting LVH in elderly patients with essential hypertension was 0.753,0.782 and 0.812,respectively.The combined value of AASI,SII and their com-bination was superior to each other(the difference was compared by DeLong method)(Z=2.594,2.109,P=0.010,0.034).Conclusion SII and AASI are independent predictors of left ventricular hypertrophy in elderly patients with essential hyper-tension,and their combination has a high predictive efficacy.