Analysis of the efficacy of metoprolol combined with irbesartan in treating hypertension complicated with heart failure
Li Huiting
Qu Lina
Zhang Zewu
Li Hao
Abstract：Objective To investigate the efficacy of metoprolol(Met)combined with irbesartan(IB)in treating hy-pertension complicated with heart failure(HF)and its impact on cardiac function.Methods A total of 112 patients with hy-pertension complicated with HF accepted by Department of Cardiology of Yan'an People's Hospital from November 2022 to December 2023 were as the research subjects,they were divided into Met group(56 cases)and IB group(56 cases)according to the random number table method.The Met group received oral metoprolol tartrate tablets,while the IB group received irbe-sartan tablets in addition to the Met group.Two groups were compared in terms of efficacy,blood pressure(BP),heart rate changes,cardiac function,endothelial function,serum inflammatory indicators,and adverse reactions.Results The total ef-fective rate of the IB group was 91.07％,which was prominently higher than the 73.21％of the Met group(x2/P=6.087/0.014).After treatment,SBP,DBP,and heart rate decreased in both groups,and the IB group was prominently lower than the Met group(t/P=2.172/0.032,5.706/＜0.001,4.641/＜0.001).After treatment,the left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),plasma endothelin(ET),angiotensin Ⅱ(Ang Ⅱ),cardiac troponinⅠ(cTnⅠ),high-sensitivity C-reactive protein(hs-CRP),N-terminal pro-brain natriuretic peptide(NT-proBNP),and tumor necro-sis factor(TNF)-α decreased in both groups,and the IB group was prominently lower than the Met group(t/P=9.060/＜0.001,10.173/＜0.001,9.560/9.187/＜0.001,4.337/＜0.001,10.377/＜0.001,7.036/＜0.001,9.837/＜0.001,9.841/＜0.001).After treatment,left ventricular ejection fraction(LVEF),nitric oxide(NO),and calcitonin gene-related peptide(CGRP)all increased,and the IB group was prominently higher than the Met group(t/P=9.187/＜0.001,4.460/＜0.001,5.376/0.040).The total incidence of adverse reactions in the Met group and IB group was 35.71％and 32.14％,respectively,and there was no statistically signifi-cant difference between the two groups(P＞0.05).Conclusion Met combined with IB has good efficacy in treating patients with hypertension complicated with HF.It can regulate BP and heart rate,enhance cardiac function,maintain vascular homeo-stasis,improve endothelial function,inhibit inflammatory response,control disease progression,and has high safety.
Keywords：HypertensionHeart failureMetoprololIrbesartanCardiac functionClinical efficacy
Publication Date：2025-06-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 646-650 )