Impacts of transcatheter left gastric artery embolization on glucose and lipid metabolisms and insulin resistance in obese rabbits with diabetes
Zhao Xi
Luo Yong
Wen Ying
Leng Qishu
Li Dan
Lyu Tingyong
Abstract：Objective To investigate the impacts of transcatheter left gastric artery embolization(LGAE)on glu-cose and lipid metabolisms and insulin resistance in obese rabbits with type 2 diabetes mellitus(T2DM).Methods The ex-perimental rabbits were assigned into a control group,a non-embolization group,and an LGAE group randomly,with 10 rab-bits in each group.A high-fat and high glucose diet combined with intraperitoneal injection of streptozotocin(STZ)was used to establish an experimental rabbit model of obesity with T2DM.After femoral artery catheterization,LGAE was guided by percutaneous catheterization.The fasting body mass,fasting blood glucose(FPG)and fasting insulin(FINS)levels of experi-mental rabbits in each group was measured and recorded before surgery and at 4th,8th,and 12th weeks after surgery,HOMA-IR and HOMA-β were calculated.The levels of serum lipid[(total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]and the Ghrelin and Leptin were detected by the kit.Results At postoperative 4th,8th,and 12th weeks,compared with the control group,fasting body mass,FPG,FINS,HOMA-IR,TC,TG,LDL-C,ghrelin and leptin levels were increased in the non-embolization group and the LGAE group,the levels of HOMA-β and HDL-C were decreased(P＜0.001).At the 4th,8th and 12th week after surgery,compared with the non-embolization group,the levels of body weight,FPG,FINS,HOMA-IR,TC,TG,LDL-C,ghrelin and leptin in the LGAE group were decreased,while the levels of HOMA-βand HDL-C were increased(4th week:t/P=9.665/＜0.001,38.240/＜0.001,39.546/＜0.001,92.674/＜0.001,34.687/＜0.001,32.193/＜0.001,42.321/＜0.001,32.194/＜0.001,39.623/＜0.001,14.770/＜0.001,23.362/＜0.001;8th week:t/P=12.490/＜0.001,39.513/＜0.001,36.943/＜0.001,106.661/＜0.001,30.934/＜0.001,24.736/＜0.001,39.583/＜0.001,31.694/＜0.001,34.430/＜0.001,13.430/＜0.001,24.794/＜0.001;12th week:t/P=15381/＜0.001,37.054/＜0.001,35.575/＜0.001,113.798/＜0.001,29.579/＜0.001,18.933/＜0.001,36352/＜0.001,31.680/＜0.001,24.839/＜0.001,10329/＜0.001,20.092/＜0.001).Conclusion LGAE guided by percutaneous catheterization can reduce blood glucose,alleviate insulin resistance,and improve lipid metabolism in obese experimental rabbits with T2DM.
Keywords：ObesityType 2 diabetes mellitusLeft gastric artery embolizationInsulin resistanceGlucose and lip-id metabolismsRabbits
Publication Date：2025-05-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 608-613 )