The predictive value of serum Nesfatin-1,Kisspeptin and FABP4 for poor pregnancy outcomes in patients with gesta-tional diabetes

Zhang Hao; Zhang Lei; Xiong Jie; Yang Sue; Wang Lili

doi:10.3969/j.issn.1671-6450.2025.05.015

Abstract：Objective To explore the predictive value of serum Nesfatin-1,Kisspeptin,and fatty acid binding pro-tein-4(FABP4)for poor pregnancy outcomes in patients with gestational diabetes.Methods From January 2023 to Sep-tember 2024,139 patients with gestational diabetes admitted to the Obstetrical Department of Tangshan Maternal and Child Health Hospital were labeled as study group.Another 139 healthy pregnant women who had normal pregnancy tests were la-beled as the healthy control group.Complying with blood glucose control status,the study group was assigned into well con-trolled group of 49 cases,poorly controlled group of 54 cases,and high-risk group of 36 cases.The study group was as-signed into good pregnancy outcome group(n=94)and poor pregnancy outcome group(n=45)based on whether the pa-tient experienced poor pregnancy outcomes.Enzyme linked immunosorbent assay was performed to detect serum Nesfatin-1,Kisspeptin,and FABP4.Logistic regression was used to analyze the influencing factors of poor pregnancy outcomes.ROC curve was drawn to analyze the efficacy of each factor alone and jointly in predicting pregnancy outcome of gestational diabetes.Results The study group had manifestly higher serum Nesfatin-1,Kisspeptin,and FABP4 than healthy control group(P＜0.05).The Nesfatin-1,Kisspeptin,and FABP4 in serum increased sequentially in well controlled group,poorly controlled group,and high-risk group(P＜0.05).Univariate analysis showed that the proportion of adverse pregnancy history,fasting blood glucose,serum Nesfatin-1,Kisspeptin,and FABP4 levels in the group with poor pregnancy outcomes were higher than those in the group with good pregnancy outcomes(P＜0.05).Multivariate logistic regression revealed that ele-vated levels of serum Nesfatin-1,Kisspeptin and FABP4 were risk factors for poor pregnancy outcome in gestational diabe-tes(P＜0.05).ROC curve revealed that the area under the curve(AUC)of serum Nesfatin-1,Kisspeptin,FABP4 and their joint in predicting poor pregnancy outcomes in patients with gestational diabetes was 0.825,0.820,0.838 and 0.939,respec-tively.The AUC of joint prediction was higher than that predicted by Nesfatin-1,Kisspeptin,and FABP4 alone(Z=4.618,4.449,3.925,P＜0.05).Conclusion The serum Nesfatin-1,Kisspeptin and FABP4 in patients with gestational diabetes are elevated,which can be used as potential indicators to predict the poor pregnancy outcome of patients.And the joint predic-tion of the three is more effective.