Expression and clinical significance of serum Omentin-1 and CS846 in elderly patients with rheumatoid arthritis

Wu Muyu; Lu Song; Tian Li; Wang Jie

doi:10.3969/j.issn.1671-6450.2025.05.014

Abstract：Objective To investigate the expression and clinical significance of serum Omentin-1 and chondroitin sulfate 846(CS846)in elderly patients with rheumatoid arthritis(RA).Methods A total of 100 elderly RA patients admit-ted to the Department of Geriatric Medicine of Dongfeng General Hospital,Hubei University of Medicine from April 2022 to April 2024 were selected as the study objects(RA group).Patients with RA were evaluated according to a 28-point joint disease activity score(DAS28)and classified into a low activity subgroup(n=43,DAS28＜5.0)and a high activity sub-group(n=57,DAS28 ≥5.0).Another 50 healthy subjects who underwent physical examination in hospital during the same period were selected as healthy control group.The levels of Omentin-1 and CS846 in serum were detected by ELISA.The correlations of serum Omentin-1 and CS846 levels with rheumatoid factor(RF),interleukin(IL)-6,tumor necrosis factor(TNF-α)and DAS28 scores were analyzed by Pearson method.ROC curve to evaluate the diagnostic value of serum Omen-tin-1 and CS846 levels in RA disease.Results Omentin-1 level in RA group was lower than that in healthy control group(t/P=9.583/＜0.001),and CS846 level was significantly higher than that in healthy control group(t/P=5.556/＜0.001).The levels of RF,IL-6 and TNF-α in RA group were higher than those in healthy control group(t/P=14.413/＜0.001,11.708/＜0.001,12.036/＜0.001).The serum Omentin-1 level of RA patients in high activity subgroup was lower than that in low activi-ty subgroup(t/P=4.914/＜0.001),and the serum CS846 level was significantly higher than that in low activity subgroup(t/P=5 272/＜0.001).Serum Omentin-1 expression was negatively correlated with RF,IL-6,TNF-α and DAS28 scores(r=-0.518,-0.435,-0.486,-0.434,all P＜0.001).Serum CS846 expression was positively correlated with RF,IL-6,TNF-αand DAS28 scores(r=0.473,0.496,0.454,0.541,all P＜0.001).The AUC of serum Omentin-1,CS846 and the combina-tion of OMentin-1 and CS846 in the diagnosis of RA were 0.882,0.755 and 0.924,respectively,and the efficacy of the combined diagnosis was better than that of single diagnosis(Z/P=2.447/0.014,4.429/＜0.001).Conclusion Serum Omentin-1 expression is decreased and CS846 expression is increased in elderly RA patients.The combined detection of the two can help diagnose RA.