The early diagnostic value of spiral CT combined with serum periostin and MASP-2 for lung cancer

Wu Chuangyu; Liu Weihong; Xu Ping; Li Xiangyun

doi:10.3969/j.issn.1671-6450.2025.05.010

Abstract：Objective To explore the early diagnostic value of spiral CT in combination with serum periostin and mannan-binding lectin-associated serine protease 2(MASP-2)for lung cancer.Methods A total of 115 suspected lung cancer patients admitted to the Oncology Department of China Resources Wuhan Steel General Hospital Affiliated to Huat-ech University from June 2022 to August 2024 were selected as the study objects.All patients underwent spiral CT exami-nation,and were divided into lung cancer group and benign lesion group using lung tissue biopsy results as the gold standard.The expression levels of serum periostin and MASP-2 were detected by ELISA.ROC curve was used to analyze the early di-agnostic value of Spiral CT,periostin and MASP-2 for lung cancer patients.Kappa analysis was employed to analyze the con-sistency of spiral CT,serum periostin,MASP-2,and combined detection in diagnosing lung cancer with the gold standard.A four-cell table was drawn to analyze the early diagnostic value of spiral CT imaging detection,serum periostin,MASP-2,and combined detection for lung cancer.Results The proportion of nodule size,"vacuole"sign,"aeration"sign,"lobed"sign and'burr"sign in lung cancer group was higher than that in benign lesion group(t/x2/P=22.188/＜0.001,5.351/0.021,6.706/0.010,10.823/0.001,10.524/0.001).Compared with the benign lesion group,the serum Periostin and MASP-2 levels were up-regulated in the lung cancer group(t/P=7.925/＜0.001,7.185/＜0.001).The AUC of spiral CT,sero-periostin,MASP-2 and their combination in the diagnosis of lung cancer were 0.896,0.864,0.844,and 0.970,respectively.The combined AUC of the three was superior to the diagnostic value of spiral CT,serperiostin,and MASP-2 respectively(Z/P=2.187/0.029,4.310/＜0.001,3.943/＜0.001).The diagnostic value of Periostin is superior to that of MASP-2.The diagnostic consistency between MASP-2 and Periostin and the gold standard for lung cancer was moderate,and the diagnostic consistency between spiral CT and the gold standard for lung cancer was strong.The combination of the three tests was in good agreement with the gold standard diagnosis of lung cancer(Kappa/P=0.604/＜0.001,0.587/＜0.001,0.460/＜0.001,0.816/＜0.001).The accuracy,sensitivity,and negative predictive value of spiral CT,Periostin,and MASP-2 combined in the diagnosis of lung cancer were higher than those of Periostin and MASP-2 alone(P＜0.05).Conclusion Periostin and MASP-2 are upregulat-ed in the serum of lung cancer patients,and the combination of spiral CT and serum Periostin and MASP-2 has a high diag-nostic value for early lung cancer.