Study on the correlation between LAP、VAI and obstructive sleep apnea-hypopnea syndrome with coronary heart dis-ease

Gulimire Aimaiti; Qiu Xuan; Chen Yulan; Yao Yanli; Wang Xingchen; Ayiguzaili Maimaitimin

doi:10.3969/j.issn.1671-6450.2025.05.009

Abstract：Objective To investigate the changes of lipid storage index(LAP)and visceral adipose index(VAI)in obstructive sleep apnea-hypopnea syndrome(OSAHS)and their predictive value for coronary heart disease(CHD).Methods A total of 671 patients suspected of having coronary heart disease who were hospitalized at the Department of Hyperten-sion,Cardiovascular Disease Center,the First Affiliated Hospital of Xinjiang Medical University between April 2020 and December 2023 were selected for this study.Based on whether there were complications of CHD,the patients were divided into two groups:CHD group(n=318)and the non-CHD group(n=353).LAP and VAI were calculated in all OSAHS pa-tients.Logistic regression analysis was conducted to identify the influencing factors for OSAHS in patients with coronary heart disease,and the receiver operating characteristic(ROC)curve was utilized to evaluate the clinical predictive value of LAP and VAI in this context.Spearman correlation analysis was used to assess the correlation between various variables and the strength of the association between coronary heart disease risk factors and Gensini score.The results were respectively reflected in the heatmap and chord diagram.Results LAP and VAI of OSAHS patients in CHD group were higher than those in non-CHD group(t/P=12.084/＜0.001,11.198/＜0.001).Logistic regression analysis showed that OSAHS with CHD was associated with male,age,hypertension,diabetes,AHI,LAP and VAI[OR(95％CI)=3.251(1.813-5.831),3.027(1.954-4.690),2.151(1297-3.567),2253(1.366-3.715),2.173(1.416-3.333),2.530(1.421-4.503),3.343(2.286-8250)];The area under the curve(AUC)of LAP,VAI,and the combination of LAP and VAI for predicting CHD in patients with OSAHS were 0.773,0.786,0.788.The combined AUC of the two is greater than the AUC of LAP,and there is no statis-tical significance compared with the AUC predicted by VAI alone(Z/P=-2.590/0.010,-0.701/0.483).Spearman analysis showed that LAP was positively correlated with TG and VAI(r=0.97,0.91),VAI was positively correlated with TG(r=0.93)and negatively correlated with HDL-C(r=-0.53).Male,age,hypertension,diabetes,AHI,LAP and VAI were positive-ly correlated with Gensini score in OSAHS patients(r=0.149,0253,0.126,0.204,0.196,0.325,0.336,P＜0.001).Conclusion LAP and VAI are independent risk factors for OSAHS complicated with coronary heart disease,and they also exacerbate the severity of coronary heart disease.The combination of the two factors holds significant application value in the early di-agnosis of OSAHS patients with comorbid CHD.