The significance of serum lncRNA taurine upregulated gene 1 and lncRNA metastasis-associated lung adenocarcinoma transcript 1 expression levels in the severity and early diagnosis of patients with Parkinson's disease
Li Jinyan
Zhu Ke
Fan Xinhong
Li Jianrui
Li Yanyan
Liu Chenyang
Abstract：Objective To investigate the relationship between the expression levels of serum lncRNA taurine up-regulated gene 1(lncRNA TUG1)and lncRNA metastasis-associated lung adenocarcinoma transcript 1(lncRNA MALAT1)and the severity of Parkinson's disease(PD)and its significance for early diagnosis.Methods One hundred and twenty PD patients admitted to the Department of Neurology,Norinco General Hospital from January 2022 to January 2024 were se-lected as the observation group.According to Hoehn-Yahr(H-Y)classification,the patients in the observation group were divided into early subgroup(grade Ⅰ-Ⅱ)46 cases and middle-late subgroup(grade Ⅲ-V)74 cases.In addition,110 healthy volunteers who underwent physical examination during the same period were selected as the healthy control group.The expression levels of serum lncRNA TUG1 and lncRNA MALAT1 in each group were detected,and the correlation be-tween them and the severity of PD was analyzed by Spearman;the clinical data of PD patients with different severity were compared,multivariate Logistic analysis was used to analyze the influencing factors affecting the severity of PD patients,the predictive value of serum lncRNA TUG1 and lncRNA MALAT1 in PD patients was detected by receiver operating curve(ROC).Results The levels of serum lncRNA TUG1 and lncRNA MALAT1 in the observation group were higher than those in the healthy control group(t/P=15.668/＜0.001,60.822/＜0.001),and the levels in the middle-late subgroup were higher than those in the early subgroup(t/P=6.670/＜0.001,17.793/＜0.001),the levels of the two were significantly positively cor-related with the severity of the disease(r/P=0.608/＜0.001,0.712＜0.001);the scores of Mini-Mental State Examination(MMSE)and Unified Parkinson's Disease Rating Scale(UPDRS)in the middle-late subgroup were higher than those in the early subgroup(t/P=5.116/＜0.001,25.014/＜0.001);High MMSE score,high UPDRS score,high lncRNA TUG1 and high ln-cRNA MALAT1 were independent risk factors affecting the severity of PD patients[OR(95％)CI=1.364(1.125-1.655),1.812(1.472-2311),4.543(1.322-7.890),5.318(1.773-9.034)].The area under curve(AUC)of serum lncRNA TUG1,lncRNA MAL-AT1 alone and their combination in predicting the severity of PD patients were 0.770,0.846 and 0.894,respectively.The AUC of combined prediction was better than that of single detection(Z=2.065,3.028,P=0.037,0.026).Conclusion Serum lncRNA TUG1 and lncRNA MALAT1 levels are closely related to the pathogenesis and progression of PD.Combined detection of the two indicators is helpful to predict the early onset of PD,and combined with its changes in serum levels,it is of great significance to determine the development of PD.
Keywords：Parkinson's diseaselncRNA taurine up-regulated gene 1lncRNA metastasis-associated lung adeno-carcinoma transcript 1Degree of severityPredictive value
Publication Date：2025-04-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 450-455 )