MI AT and HbA1c expression in peripheral blood of patients with diabetes and central obesity and their predictive value for microvascular complications

Qiao Yan; Yi Shiqiong; Teng Yun; Wang Feng

doi:10.3969/j.issn.1671-6450.2025.04.005

Abstract：Objective To explore the expression levels of myocardial infarction-associated transcription factor(MI-AT)mRNA and glycated hemoglobin(HbA1c)in peripheral blood of patients with diabetes and central obesity and their pre-dictive value for microvascular complications.Methods Two hundred and twelve patients with diabetes and central obesity admitted to our hospital from May 2021 to March 2023 were prospectively selected as the observation group,and 212 healthy people who underwent physical examination during the same period were selected as the healthy control group.Ear-ly morning fasting peripheral blood was collected from all study subjects,and their MIAT mRNA and HbA1c expression lev-els were detected.The patients were followed up for 1 year and were divided into a complication group(n=86)and a no-complication group(n=126)according to whether they developed microvascular complications.The ROC curve was used to analyze the predictive value of patients'serum MIAT mRNA and HbA1c levels for microvascular complications.Results Compared to the healthy control group,the expression levels of MIAT mRNA and HbA1c were increased in the observation group(t/P=28299/＜0.001,22.952/＜0.001).Logistic regression results showed that age(OR=1.450,95％CI1.141-2.093,P=0.016),BMI(OR=1325,95％CI 1.059-1.799,P=0.037),disease duration(OR=2.137,95％CI 1.430-2.786,P＜0.001),Hyperlipidemia(OR=2 368,95％CI 1.626-3.439,P＜0.001),fasting blood glucose(OR=2.705,95％CI 1.909-5.172,P＜0.001),MIAT mRNA(OR=2.449,95％CI1.753-3.652,P＜0.001),HbA1c(OR=1.934,95％CI1.329-2.646,P＜0.001)are risk factors for microvascular complications.According to ROC curve analysis,the sensitivity and specificity of serum MIAT mRNA detection alone is 0.767 and 0.619,and the area under curve is 0.719.The sensitivity and specificity of HbA1c detec-tion alone are 0.640 and 0.802.The sensitivity of combined detection of serum MIAT mRNA and HbA1c is 0.744,the speci-ficity is 0.810,and the area under curve is 0.825.Conclusion The expression levels of MIAT and HbA1c in peripheral blood of patients with diabetes mellitus and central obesity increased,and the combined detection of the two had a high predictive value for microvascular complications.