A study on the changes of intraocular cytokines in aqueous humor of DME patients undergoing anti-VEGF therapy and their correlation with SD-OCT imaging characteristics
Li Huan
Wang Wei
Wang Yunchang
Dong Ping
Abstract：Objective To investigate the changes of intraocular cytokines and spectral domain optical coherence tomography(SD-OCT)in patients with diabetes macular edema undergoing anti vascular endothelial growth factor treatment,and the impact on prognosis.Methods Eighty patients with DME were selected,and cytokine detection in aqueous humor was completed before receiving anti VEGF treatment.The correlation between these factors and the SD-OCT imaging charac-teristics of the patients before and after treatment was analyzed.Results The levels of IL-6,IL-8,TNF-α,and VEGF in the aqueous humor of the observation group were higher than those in the control group(t/P=18.836/＜0.001,25.756/＜0.001,7.321/＜0.001,16.937/＜0.001);The levels of IL-6,IL-8,VEGF in the aqueous humor of DME patients in the treatment insen-sitive subgroup,as well as the number of HF and the proportion of interruption of external membrane continuity,were lower than those in the treatment sensitive subgroup(t/P=3.767/＜0.001,2.867/0.005,2.193/0.031,3.353/0.001,7.011/0.008);The VEGF levels and CMT thickness in the aqueous humor of DME patients in the interrupted subgroup were higher than those in the continuous subgroup(t/P=2.732/0.008,2.193/0.031);The CMT of DME patients with elevated VEGF after anti VEGF treatment was lower than that before treatment(t/P=8.999/＜0.01);The number of HF in DME patients is weakly positively correlated with VEGF levels in aqueous humor,and moderately positively correlated with IL-6 and IL-8 levels in aqueous hu-mor(r/P=0.301/0.007,0.536/0.023,0.788/＜0.001).Conclusion HF and interruption of ELM can be used as an observation indicator to evaluate the therapeutic effect of anti-VEGF.The patient's insensitivity to anti VEGF treatment may be consid-ered as treated with hormonal drugs.
Keywords：Diabetes macular edemaAnti VEGFSD-OCTInflammatory factorsCorrelation
Publication Date：2025-03-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 349-353 )