Analysis of the correlation between serum TRAF6,CTRP9 levels and fetal growth restriction in pregnant women with hypertension disorders in pregnancy

Wang Min; Zhou Jing; Ma Rui; Liu Xing; Yang Wenjing

doi:10.3969/j.issn.1671-6450.2025.03.013

Abstract：Objective To analyze the correlation between serum tumor necrosis factor receptor associated factor 6(TRAF6),complement C1q tumor necrosis factor related protein 9(CTRP9)levels and fetal growth restriction(FGR)in preg-nant women with hypertension disorders in pregnancy(HDP).Methods From February 2021 to February 2024,110 preg-nant women with HDP treated in Department of Obstetrics and Gynecology,Northwest Women and Children's Hospital were selected.According to fetal growth,they were assigned into two groups:the observation Group(39 cases)and the control group(71 cases).Enzyme linked immunosorbent assay(ELISA)was used to detect serum levels of TRAF6 and CTRP9.Measure the fetal biparietal diameter,femoral length,abdominal circumference,head circumference and BMI value after birth.All basic information of the research subjects was statistically analyzed.Spearman method was used for correlation analysis.The risk factors affecting FGR in pregnant women with HDP were analyzed using a multiple logistic regression model.ROC was used to analyze the predictive value of serum TRAF6 and CTRP9 for FGR in pregnant women with HDP.Results Compared with the control group,pregnant women in the observation Group had higher serum TRAF6,lower serum CTRP9(t/P=5.962/＜0.001,5.848/＜0.001),and higher proportions of vitamin D deficiency,abnormal umbilical blood flow,and pla-cental abnormalities(x2/P=8.506/0.004,41.412/＜0.001,31.174/＜0.001).Besides,lower indexes biparietal diameter,femur length,and abdominal circumference,head circumference and BMI values after birth in the observation Group(t/P=8.947/＜0.001,12.560/＜0.001,5.118/＜0.001,7.307/＜0.001,8.930/＜0.001).The serum TRAF6 was positively correlated with vitamin D deficiency,abnormal umbilical blood flow,placental abnormalities,and FGR occurrence(r/P=0.492/＜0.001,0.423/＜0.001,0.568/＜0.001,0.422/＜0.001;while the serum CTRP9 was negatively correlated with vitamin D deficiency,abnormal umbilical blood flow,placental abnormalities,and FGR occurrence(r/P=-0.513/＜0.001,-0.416/＜0.001,-0.594/＜0.001,-0.419/＜0.001).High serum TRAF6 is an influencing factor for FGR in pregnant women with HDP,and high CTRP9 is a protective factor for FGR in pregnant women with HDP[OR(95％CI)=1.995(1.166-3.413),0.354(0.190-0.658)],The AUC values of serum TRAF6,CTRP9 levels and their combination for predicting FGR in pregnant women with HDP were 0.858,0.826 and 0.938,respectively.The combination of the two was superior to the single prediction efficiency(Z=2.820,3.510,P=0.005,P＜0.001).Conclusion The levels of TRAF6 and CTRP9 are elevated in the serum of HDP pregnant women with FGR.Both are closely related to vitamin D deficiency,abnormal umbilical blood flow,placental abnormalities,and FGR occurrence in pregnant women with HDP.In addition,TRAF6 and CTRP9 are also factors that affect the occurrence of FGR in pregnant women with HDP,and their combination can predict the occurrence of this complication.