Correlation between serum salusin-β,sNogo-B with disease progression and cognitive impairment in Parkinson's dis-ease patients

Lu Lixia; Wu Weiwen; Wang Yang; Chen Lin; Zhao Jun

doi:10.3969/j.issn.1671-6450.2025.03.011

Abstract：Objective To investigate the correlation between serum salusin-β,soluble neurite outgrowth inhibitor-B(sNogo-B)with disease progression and cognitive impairment(CI)in Parkinson's disease(PD)patients.Methods From January 2021 to December 2023,124 PD patients in the Department of Neurology,Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University were selected as PD group,and 85 healthy people in the same period were selected as healthy control group.PD patients were divided into early subgroup(n=56)and middle and late subgroup(n=68)according to their disease progression,and then divided into PD-NCI subgroup(n=52)and PD-CI subgroup(n=72)according to whether PD patients were accompanied by CI or not.Serum levels of salusin-β and sNogo-B were detected by enzyme-linked immunosorbent assay.Hoehn-Yahr staging was used to stage the disease progression of PD patients;The Montreal Cognitive Assessment Scale(MoCA)was used to evaluate the cognitive function of PD patients.Spearman correlation anal-ysis was used to analyze the correlation between serum salusin-β and sNogo-B levels and disease progression and CI in PD patients.Diagnostic value of analyzing serum salusin-β and sNogo-B levels by ROC curve in PD patients with disease pro-gression and accompanying CI.Results The serum levels of salusin-β and sNogo-B in PD group were lower than those in healthy control group(t/P=8.694/＜0.001,7.923/＜0.001).The serum levels of salusin-β and sNogo-B in the middle and late subgroup were lower than those in the early subgroup(t/P=6.709/＜0.001,7.059/＜0.001).Serum salusin-β and sNo-go-B levels in PD-CI subgroup were lower than those in PD-NCI subgroup(t/P=6.062/＜0.001,8.767/＜0.001).The serum levels of salusin-β and sNogo-B in PD patients were negatively correlated with the progression of the disease and accom-panying CI(r=-0.408,-0.412,-0.403,-0.406,all P＜0.001).The AUC of serum salusin-β,sNogo-B and their combined diagnosis of PD patients with CI were 0.796,0.820 and 0.918,respectively.The AUC of serum salusin-β and sNogo-B was higher than that predicted by serum Salusin-β and Snogo-B alone(Z=3.702,3.044,P＜0.001,0.002).Conclusion The serum levels of salusin-β and sNogo-B in PD patients are low,and further decrease with the disease progression and ac-companying CI.Compared with single diagnosis,the combined diagnosis of salusin-β and snogo-B has higher value,which provides theoretical support for clinical diagnosis.