Changes of blood routine indexes,tumor markers and chemokines in breast cancer patients after radiotherapy and their predictive value for cancer recurrence
Sang Juan
Yue Wen
Liu Haifeng
Zhang Zegao
Abstract：Objective To investigate the changes of blood routine indexes,tumor markers and chemokines in breast cancer patients after radiotherapy and their predictive value for cancer recurrence.Methods One hundred and two patients with breast cancer from our hospital were enrolled in this study from April 2020 to May 2022.All patients received breast-conserving surgery and postoperative adjuvant radiotherapy,and were divided into non-recurrence group(n=80)and recurrence group(n=22)according to the recurrence within one year after radiotherapy.General clinical data[age,body mass index(BMI),diabetes history,hypertension history,TNM stage,tumor size,course of disease,location of cancer,pathological type],blood routine indicators[neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),monocyte/lymphocyte ratio(MLR)],tumor markers[carbohydrate antigen(CA)-125,CA153,CA199,carcinoembryonic antigen(CEA)]and chemokines[CC chemokine ligand(CCL)-2,CCL-8,CCL-21]were compared between the groups.Spearman correlation analysis and multivariate Logistic regression analysis were used to screen the risk factors of cancer recurrence in breast cancer patients after radiotherapy.Results The mean NLR,PLR and MLR levels in relapsed group were significantly higher than those in non-relapsed group(t/P=4.274/＜0.001,3.386/＜0.001,4.983/＜0.001).There were no significant differences in average CA125,CA153,CA199 and CEA levels between the two groups(P＞0.05).The CCL8 and CCL21 levels were signifi-cantly higher than those in non-relapse group(t/P=4.529/＜0.001,4.480/＜0.001).Spearman correlation analysis showed that TNM grade,NLR,PLR,MLR,CCL8 and CCL21 levels were significantly positively correlated with cancer recurrence(r/P=0.211/0.033,0.420/＜0.001,0.322/0.001,0.382/＜0.001,0.436/＜0.001,0.393/＜0.001).Multivariate Logistic regression analysis showed that higher levels of NLR,PLR,MLR,CCL8 and CCL21 were risk factors for cancer recurrence[OR(95％CI)=3.579(1.397-9.140),1.043(1.003-1.084),3.113(1.330-9.168),1.061(1.015-1.109),1.032(1.002-1.174)].Conclusion The higher levels of NLR,PLR,MLR,CCL8 and CCL21 in breast cancer patients after breast conserving surgery are closely related to cancer recurrence.Monitoring these indicators in breast cancer patients has certain clinical value for auxiliary prediction of cancer recurrence.
Keywords：Breast cancerBreast-conserving surgeryPostoperative radiotherapyChemokinesCancer recurrence
Publication Date：2025-03-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 309-312,317 )