The predictive value of serum MIP-1α,FGF-23,and HDAC3 for recurrence in patients with paroxysmal atrial fibril-lation after radiofrequency ablation
Zhang Qingjun
Xue Jun
Fan Yudong
Wu Di
Zhang Zilong
Abstract：Objective To investigate the predictive value of serum macrophage inflammatory protein-1α(MIP-1α),fibroblast growth factor-23(FGF-23),and histone deacetylase 3(HDAC3)for recurrence in patients with paroxysmal atrial fi-brillation(PAF)after radiofrequency ablation(RFA).Methods A total of 245 PAF patients who received RFA treatment in Emergency General Hospital from June 2021 to June 2023 were included as the study group.They were assigned into a re-currence group(64 cases)and a non-recurrence group(181 cases)based on their recurrence status 12 months after RFA.A total of 245 healthy subjects were selected as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect the levels of serum MIP-1α,FGF-23,and HDAC3.Pearson correlation was applied to analyze the correlation be-tween serum MIP-1α,FGF-23,HDAC3 levels and left atrial anterior posterior diameter(LAD),left atrial volume index(LAVI),and left ventricular ejection fraction(LVEF)in patients with PAF.Multi-factor Logistic regression model was applied to ana-lyze the factors affecting the recurrence of RFA in PAF patients.ROC curve was applied to evaluate the predictive value of MIP-1α,FGF-23,and HDAC3 for recurrence in PAF patients after RFA.Results The levels of serum MIP-1α,FGF-23,HDAC3,LAD,and LAVI in the study group were higher than those in the control group,while the LVEF in the study group was lower than that in the control group(t=88.773,83.283,55.911,36.510,31.806,37.894,all P＜0.001).According to Pearson correlation analysis,serum MIP-1α,FGF-23,and HDAC3 in PAF patients were positively correlated with LAD and LAVI,and negatively correlated with LVEF(MIP-1α:r/P=0.534/＜0.001、0.621/＜0.001、-0.582/＜0.001;FGF-23:r/P=0.479/＜0.001、0.637/＜0.001、-0.609/＜0.001;HDAC3:r/P=0.515/＜0.001、0.674/＜0.001、-0.715/＜0.001).The proportion of pa-tients aged ≥60 years,the proportion of patients with concomitant coronary heart disease(CHD),the levels of serum MIP-1α,FGF-23,HDAC3,and the LAD and LAVI in the recurrence group were higher than those in the non-recurrence group,the duration of PAF in the recurrence group was longer than that in the non-recurrence group,the LVEF in the recurrence group was lower than that in the non-recurrence group(t/x2=12.861,11.022,32.826,5.286,7.312,9.581,28.965,29.296,25.505,all P＜0.001).Multivariate Logistic regression analysis showed that MIP-1α,FGF-23,HDAC3,and CHD were risk factors for recurrence in PAF patients after RFA[OR(95％CI)=2.684(1.376-5.237),2.349(1.419-3.887),3.124(1.407-6.937),3.017(1.312-6.940)].The AUC value of serumMIP-1α,FGF-23,and HDAC3 and their combination for predicting recurrence in PAF patients after RFA was 0.747,0.777,0.769,and 0.912,respectively.The AUC value of the combined detection of the three was higher than that of the independent detection of MIP-1α,FGF-23 and HDAC3(Z=3.940,3.356,3.414,all P＜0.001).Conclusion The levels of serum MIP-lα,FGF-23,and HDAC3 are all elevated in PAF patients who experience re-currence after RFA.The combined detection of the three can improve the predictive value for recurrence in PAF patients af-ter RFA.
Keywords：Paroxysmal atrial fibrillationRadiofrequency ablationMacrophage inflammatory protein-1αFibroblast growth factor-23Histone deacetylase 3Prognostic value
Publication Date：2025-03-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 268-273 )