Effects of serum levels of leptin,TNF-α and IL-6 on lung function and asthma control in children with obese asthma
Zang Chunhui
Li Shiyun
Zhang Wen
Xiu Linying
Chen Ying
Wang Shuyu
Abstract：Objective To investigate the effects of serum levels of leptin,tumor necrosis factor-α(TNF-α)and in-terleukin-6(IL-6)on lung function and asthma control in children with obese asthma.Methods A prospective study was conducted on 103 children with obese asthma from September 2020 to August 2023 in our hospital as study group,103 non-obese children with asthma from the same period as non-obese asthma group,and 103 healthy children who underwent physical examination as a healthy control group.The levels of serum leptin,TNF-α,and IL-6 were compared among the three groups,the relationship was analyzed between serum leptin,TNF-α,and IL-6 levels and lung function in obese chil-dren with asthma,and their predictive value for asthma control was evaluated.Results The levels of serum leptin,TNF-α,and IL-6 in the study group＞non-obese asthma group＞healthy control group(F/P=21.723＜0.001、104.516/＜0.001、62.026/＜0.001).The levels of serum leptin,TNF-α,and IL-6 in children with severe asthma＞children with moderate asthma＞children with mild asthma(F/P=23.660/＜0.001、33.615/＜0.001、26.434/＜0.001).After4 weeks of treatment,31 ca-ses were completely controlled(included in the complete control subgroup),45 cases were partially controlled(included in the partial control subgroup),and 27 cases were not controlled(included in the uncontrolled subgroup).There was no sig-nificant difference in gender,age,and BMI among the three subgroups(P＞0.05).There was a significant difference in the severity of the disease among the three subgroups(x2/P=23.441/＜0.001).FVC,FEV1,and PEF showed a gradual down-ward trend in the complete controlled subgroup,partially controlled subgroup,and uncontrolled subgroup(F/P=23.083/＜0.001、22.823/＜0.001、34.771/＜0.001),while the levels of serum leptin,TNF-α,and IL-6 showed a gradual upward trend in the complete controlled subgroup,partially controlled subgroup,and uncontrolled subgroup(F/P=38.883/＜0.001、122.302/＜0.001、29.940/＜0.001).The levels of serum leptin,TNF-α,and IL-6 were negatively correlated with FVC,FEV1,and PEF(r=-0.622、-0.640、-0.603,-0.662、-0.609、-0.594,-0.703、-0.625、-0.619,P均＜0.001).The AUC of serum lep-tin,TNF-α,and IL-6 for predicting asthma control was 0.734,0.778,and 0.767,which was significantly better than the predic-tive value of each indicator alone(Z=3.712,3.065,3214,all P＜0.001).Conclusion Serum leptin,TNF-α,and IL-6 are ab-normally elevated in obese children with asthma,and are closely related to the severity of the disease and lung function.Combined detection can reliably predict the control of asthma.
Keywords：Obese asthmaLeptinTumor necrosis factor-αInterleukin-6Lung functionAsthma controlChil-dren
Publication Date：2025-02-17
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)