The correlation between serum Lipocalin-2,Ficolin-2 and vascular restenosis after interventional treatment of lower extremity arteriosclerosis obliterans

Shan Shaoyin; Zhao Liubing; Tong Yuanhao; Liu Chao; Zhang Weiran; Shen Jingfu; Han Zhifeng

doi:10.3969/j.issn.1671-6450.2025.02.011

Abstract：Objective To investigate the correlation between serum Lipocalin-2,Ficolin-2,and vascular restenosis after interventional treatment of lower extremity arteriosclerosis obliterans(LEASO).Methods A total of 130 patients with LEASO who underwent interventional therapy in the Department of Vascular Surgery,Mingji Hospital Affiliated to Nanjing Medical University from January 2018 to June 2023 were selected as the LEASO group.According to whether vascular rest-enosis occurred during the 1-year follow-up,LEASO patients were divided into restenosis subgroup of 40 cases and non-restenosis subgroup of 90 cases.80 cases of healthy physical examination in the hospital during the same period were select-ed as healthy control group.The levels of serum Lipocalin-2 and Ficolin-2 were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was used to analyze the correlation between serum Lipocalin-2,Ficolin-2 levels and lu-men diameter reduction rate in LEASO patients.Multivariate Logistic regression analysis was used to analyze the influen-cing factors of vascular restenosis after interventional therapy in LEASO patients.The receiver operating characteristic(ROC)curve was used to evaluate the predictive efficacy of serum Lipocalin-2 and Ficolin-2 levels on vascular restenosis af-ter interventional therapy in LEASO patients.Results The serum levels of Lipocalin-2 and Ficolin-2 in the LEASO group were higher than those in the healthy control group,and the differences were statistically significant(t/P=23.943/＜0.001,29.774/＜0.001);Serum Lipocalin-2 and Ficolin-2 levels in LEASO patients were positively correlated with lumen diameter re-duction rate(r/P=0.719/＜0.001,0.730/＜0.001);After 1 year of interventional therapy,the incidence of vascular restenosis in 130 patients with LEASO was 30.77％(40/130).The proportion of diabetes,hypertension and serum Lipocalin-2 and Fi-colin-2 levels in the restenosis subgroup were higher than those in the non-restenosis subgroup,and the differences were statistically significant(x2/t/P=6.945/0.008,6.644/0.010,6295/＜0.001,5.657/＜0.001);Diabetes,high Lipocalin-2 and high Fico-lin-2 were independent risk factors for vascular restenosis after interventional therapy in patients with LEASO[OR(95％CI)=3.383(1.187-9.647),1264(1.120-1.427),1272(1.113-1.454)];The AUC of serum Lipocalin-2,Ficolin-2 levels and their com-bination in predicting vascular restenosis after interventional therapy in LEASO patients were 0.789,0.786 and 0.875,respec-tively.The AUC predicted by the combination of the two was greater than that predicted by serum Lipocalin-2 and Ficolin-2 levels alone,and the difference was statistically significant(Z/P=2.502/0.012,2.339/0.019).Conclusion The levels of serum Lipocalin-2 and Ficolin-2 in patients with LEASO are increased,which is closely related to vascular restenosis after interven-tional therapy.The combination of serum Lipocalin-2 and Ficolin-2 levels has a high predictive efficiency for vascular rest-enosis after LEASO interventional therapy.