Analysis of the diagnostic value of MRI examination parameters combined with serum C-myc and CK19 for primary liver cancer
He Teng
Wang Yang
Chen Menglong
Xia Yimerdan Yibulayin
Liu Chen
Ming Jie
Abstract：Objective To explore the diagnostic value of magnetic resonance imaging(MRI)combined with serum C-myc and cytokeratin 19(CK19)in primary liver cancer.Methods Case data of 86 patients with primary liver cancer(pri-mary liver cancer group)and 71 patients with benign liver disease(benign liver disease group)admitted to our hospital from April 2022 to July 2024 were collected,and all patients underwent MRI examination.ELISA method was applied to detect the levels of serum C-myc and CK19 in patients.ROC curve was applied to analyze the diagnostic value of MRI examination pa-rameters Kep,Ktrans,Ve and serum C-myc,CK19 for primary infections.Kappa test was applied to analyze the consistency between MRI alone and in combination with serum C-myc and CK19 levels in diagnosing primary liver cancer and pathologi-cal results.Results The MRI parameters Kep,Ktrans,Ve,and serum C-myc and CK19 levels in the primary liver cancer group were higher than those in the benign liver disease group(t/P=7.968/＜0.001,8.499/＜0.001,8.178/＜0.001,8.368/＜0.001,8.034/＜0.001).The AUC values for diagnosing primary liver cancer using MRI parameters Kep,Ktrans,Ve,serum C-myc,CK19 alone and combined were 0.837,0.859,0.858,0.804,0.817 and 0.952,respectively(Z/P=3.059/0.002、2.658/0.008、2.687/0.007、3.847/＜0.001、3509/＜0.001).The consistency test between MRI diagnosis of primary liver cancer and pathological results showed a Kappa value of 0.698(P＜0.001).The consistency test between MRI combined with serum C-myc and CK19 in the diagnosis of primary liver cancer and pathological results showed a Kappa value of 0.897(P＜0.001).The negative predictive value,accuracy,and sensitivity of MRI combined with serum C-myc and CK19 in the diagnosis of primary liver cancer were higher than those of MRI alone(x2/P=9.665/0.002,8.908/0.003,13.526/＜0.001).Conclusion MRI combined with serum C-myc and CK19 is more effective in diagnosing primary liver cancer than MRI alone,and can provide reference for early di-agnosis of primary liver cancer.
Keywords：Primary liver cancerMagnetic resonance imagingC-mycCytokeratin 19Diagnostic value
Publication Date：2025-02-17
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)