Research progress on NRF2-mediated ferroptosis in neonatal hypoxic-ischemic encephalopathy
Tang Jiaxin
Fang Chengzhi
Zhang Binghong
Abstract：Neonatal hypoxic-ischemic encephalopathy(HIE)is a common neonatal disease with high rates of disa-bility and mortality,lacking specific therapeutic approaches.The critical mechanism of HIE involves oxidative stress induced by the excessive generation of reactive oxygen species(ROS)and diminished antioxidant capacity.Ferroptosis,a form of programmed cell death triggered by iron-dependent lipid peroxidation and ROS accumulation,plays a significant role in the development of HIE.Nuclear factor E2-related factor 2(NRF2)is the main regulator of oxidative stress response in humans,and extensive studies have shown that NRF2 regulates a variety of genes related to brain iron metabolism and ferroptosis,suggesting its potential to inhibit iron-induced cell death in HIE.Therefore,this review focuses on the protective role of NRF2 in HIE by elucidating the interplay among ferroptosis,HIE,and NRF2.
Keywords：Neonatal hypoxic-ischemic encephalopathyFerroptosisNuclear factor E2-related factor 2Lipid per-oxide
Publication Date：2025-01-17
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)