Healing effect of Sanqi Tongshu Capsules combined with vinpocetine on acute cerebral infarction and its effects on se-rum hs-CRP and IL-10 levels

Li Yan; Liu Hui; Yang Xue; Jiang Jian; Kong Zhaohong

doi:10.3969/j.issn.1671-6450.2025.01.003

Abstract：Objective To investigate the healing effect of Sanqi Tongshu Capsules combined with vinpocetine on acute cerebral infarction and its effects on the levels of serum high-sensitivity C-reactive protein(hs-CRP)and interleukin-10(IL-10).Methods Ninety patients with acute cerebral infarction admitted to our hospital(December 2022 to December 2023)were selected as the research subjects and randomly separated into a single group and a combination group,with 45 pa-tients in each group.The single group was treated with vinpocetine injection,while the combination group was treated with Sanqi Tongshu Capsules on the basis of the single group.The Behavioral and cognitive functions,quality of life,vascular endothelial function related indicators,hemorheological indicators,inflammatory factor levels before treatment(T0)and 2 weeks after treatment(T1),and healing effect were observed in both groups.Results After 2 weeks of treatment,the total effective rate of the combined group(95.56％)was higher than that of the single group(77.78％)(x2/P=6.154/0.013).After 2 weeks of treatment,the scores of daily living Scale(ADL)and simple Intelligent Mental State Examination Scale(MMSE)were increased in both single group and combined group.The combined group was significantly higher than the single group(t/P=2 384/0.019,3.774/＜0.001).The scores of all items in the Comprehensive Assessment of Quality-of-Life question-naire(GQOLI-74):material life status,physical function,psychological function,social function and overall quality of life fac-tor were all increased.The combined group was significantly higher than the single group(t/P=2.785/0.007,2 339/0.022,2.196/0.031,3.378/0.001,8.341/＜0.001);The levels of nitric oxide(NO)and IL-10 were increased,endothelin-1(ET-1)and hs-CPR were decreased,and the increases/decreases in combination group were greater than those in single group(t=4.612,4.390,3.841,10.154,all P＜0.001).Whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity and fibrino-gen water were significantly decreased on average(P＜0.001),and the combined group was significantly lower than the sin-gle group(t=9.959,10.265,23.694,16.993,10.154,4.390,all P＜0.001).Conclusion The combination of Sanqi Tongshu Cap-sules and vinpocetine has prominent healing effects on acute cerebral infarction,it can improve blood circulation,reduce in-flammatory reactions,and enhance cognitive behavioral function and quality of life.