The relationship between autoimmune gastritis complicated with Helicobacter pylori infection and gastric cancer

Kong Wenjie; He Huan; Liu Weidong; Hui Wenjia; Yu Lin; Hu Xinhui; Zhang Mengxia; Gao Feng

doi:10.3969/j.issn.1671-6450.2024.11.002

Abstract：Objective Investigating the relationship between autoimmune gastritis,Helicobacter pylori infection and gastric cancer through a retrospective cohort study.Methods Patients with autoimmune gastritis in our hospital were enrolled and divided into non-Hp group(n=225)and an Hp group(n=91)according to the status of Helicobacter pylori infection.The baseline characteristics,OLGA and OLGIM stages,screening indicators of gastric cancer,incidence and loca-tion of gastric cancer were statistically analyzed between the two groups.The incidence of gastric cancer was further com-pared between the two subgroups.Results Compared with non-Hp group,there were no statistically significant differences in PCA and IFA positive proportion in Hp group(x2/P=0.191/0.662,0.277/0.599);The level of PG Ⅰ and PG Ⅰ/PGⅡ in Hp group decreased(t/P=2.133/0.034,2.001/0.046),and G-17 increased(t/P=2.045/0.042);Compared with past infection sub-groups,active infection subgroup of patients with a significant rise in 14C breath test results(t/P=34.99/＜0.05);The aver-age time from infection to enrolled group in past infection subgroups was(2.12±0.94)years;Compared with the non-Hp group,the performance of OLGA and OLGIM staging in Hp group were worse(41.76％vs.25.33％,19.78％vs.1022％,x2/P=8.314/0.004,5242/0.022),and the gastric cancer risk is higher(112.09％vs.5.33％,x2/P=4.380/0.036);The incidence of gastric body and cardia cancer in Hp group was significantly lower,and the incidence of gastric antrum cancer was signifi-cantly higher(5833％vs.100％,36.36％vs.0％,P=0.037).Compared with the previous infection subgroup,the incidence of gastric cancer in the active infection subgroup was higher(27.78％vs.822％,x2/P=5.198/0.023).Conclusion The risk of gastric cancer in AIG patients with Hp infection,especially active Hp infection,is significantly higher than that in AIG pa-tients without HP infection.