The value of serum α2δ-1 and RvD1 in evaluating the condition and prognosis of patients with acute cerebral hemor-rhage

Hu Jiao; Wang Fei; Luo Rong; Yang Jing; Li Shulin

doi:10.3969/j.issn.1671-6450.2024.09.006

Abstract：Objective To explore the clinical application value of serum calcium channel α2δ-1 and Resolvin D1(RvD1)levels in evaluating the condition and prognosis of patients with acute cerebral hemorrhage.Methods A total of 126 patients with acute cerebral hemorrhage admitted to the Emergency Department of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from January 2022 to December 2023 were selected as the study group.Accord-ing to the prognosis of patients followed up for 6 months,they were divided into 52 cases of poor prognosis subgroup and 74 cases of good prognosis subgroup.In addition,60 healthy people who underwent physical examination in the hospital during the same period were selected as healthy control group.The levels of serum α2δ-1 and RvD1 were measured by en-zyme linked immunosorbent assay.Multivariate Logistic regression analysis was used to analyze the influencing factors of poor prognosis in patients with acute cerebral hemorrhage.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum α2δ-1 and RvD1 levels on the poor prognosis of acute cerebral hemorrhage.Results The serum α2δ-1 level in the study group was higher than that in the healthy control group,and the serum RvD1 level was lower than that in the healthy control group(t=28379,16.412,all P＜0.001).With the aggravation of the disease,the level of serum α2δ-1 in patients with acute cerebral hemorrhage gradually increased,and the level of serum RvD1 gradually decreased(F=109.100,54.370,P＜0.001).The incidence of 6-month poor prognosis in 126 patients with acute cerebral hemor-rhage was 4127％ (52/126).The age,NIHSS score,hematoma volume,serum α2δ-1,and time from symptom onset to admis-sion in the poor prognosis subgroup were higher than those in the good prognosis subgroup(t=3 331,27.914,21.449,6.056,2.301,all P＜0.05),and the serum RvD1 level was lower than that in the good prognosis subgroup(t=5.824,P＜0.001).Mult-ivariate logistic regression results showed that high NIHSS score,large hematoma volume,and high α2δ-1 were independent risk factors for poor prognosis in patients with acute cerebral hemorrhage[OR(95％ CI)=2.361(1.694-3.101),2.147(1.514-2.798),1.665(1262-2.995)],and high RvD1 was an independent protective factor[OR(95％ CI)=0.389(0.255-0.662)];the AUC of serum α2δ-1,RvD1 levels and their combined prediction of poor prognosis in patients with acute cerebral hemor-rhage were 0.756,0.780 and 0.841,respectively.The area under the curve(AUC)of the combination of the two was greater than the AUC predicted by serum α2δ-1 and RvD1 levels alone(Z=2.623,2.127,P=0.009,0.033).Conclusion Serum α2 δ-1 and RvD1 levels can reflect the severity of patients with acute cerebral hemorrhage,and can be used as an auxiliary predic-tor of poor prognosis.The combination of the two has a high value in evaluating the prognosis of patients with acute cere-bral hemorrhage.