Effects of Tongxinluo Capsule on sepsis and microcirculation parameters

Liu Yujin; Dong Jing; Sun Yaying; Zhang Wei; Wu Yansong; Wang Zhiyong; Li Yunchao

doi:10.3969/j.issn.1671-6450.2024.08.013

Abstract：Objective To observe the effects of Tongxinluo Capsule on major circulation parameters(MAP,CVP and ScvO2),micro circulation parameters(Pcv-aCO2,Pcv-aCO2/Ca-cvO2,Lac,CRT),clinical efficacy,APACHE-Ⅱ,SOFA score,mechanical ventilation time,ICU admission time and 28-day mortality in septic patients.Methods Sixty patients with sepsis were randomly divided into treatment group and control group,30 cases in each group,both groups were given con-ventional western medicine,the treatment group plus Tongxinluo Capsule,the control group plus placebo,4 capsules,3 times a day,the course of treatment for 7 days.Blood samples were collected at 0,6,24,48 and 72 hours after ICU admis-sion respectively,and relevant research indexes were detected.Results The total effective rate of treatment group was sig-nificantly higher than that of control group(100.0％vs.66.7％,x=8.857,P=0.003).The intra-group comparisons of large cycle parameters MAP,CVP and ScvO2 at different time points of 0h,6h,24h,48h and 72 h in the both groups were all sta-tistically significant(all P＜0.001),and no significance between the two groups(all P＞0.05).In the control group,Pcv-aCO2 was significantly different in the above 5 different time points(P=0.006),but no significance in Pcv-aCO2/Ca-cvO2(P=0261).The intra-group comparisons of Pcv-aCO2 and Pcv-aCO2/Ca-cvO2 in treatment group were all statistically significant(all P＜0.05).There were no significances in Pcv-aCO2 and Pcv-aCO2/Ca-cvO2 between the 2 groups at 0h,6h and 24h(all P＞0.05),but there were significances between the 48h and 72h(all P＜0.05),and the treatment group was superior to the control group.Lac and CRT were statistically significant in the above 5 different time points with intra-group comparisons of the both groups(all P＜0.001).There were no significances in Lac levels between the 2 groups at 0h,6h,24h and 48 h(all P＞0.05),but there was a statistically significant difference between the groups at 72 h(P=0.036),and the treatment group was better than the control group.No significances were found in CRT between groups at 0h,6h and 24h(all P＞0.05),but there were significances between groups at 48h and 72 h(all P＜0.05),and the treatment group was superior to the control group.There were no significant differences in APACHE-Ⅱ and SOFA scores between the two groups before treatment(P all＞0.05).There were significant differences before and after treatment with intra-group comparison of both groups(all P＜0.001).After 7 days of treatment,there was no significant difference in APACHE-Ⅱ scores among groups(P＞0.05),while significant difference was found in SOFA scores among groups(P=0.010).The treatment group was better than the control group.But there were no significant differences in mechanical ventilation time,ICU admission time and 28-day mortality be-tween the two groups(all P＞0.05).Conclusion Tongxinluo Capsule can improve the microcirculation disorder of sepsis pa-tients,relieve the condition and improve the clinical efficacy of TCM syndromes,but it cannot shorten the mechanical venti-lation time,ICU admission time and 28-day mortality.