Diagnosis and prognosis assessment of serum FIZZ2 in patients with AECOPD complicated with respiratory failure
Li Zhilin
Niu Li
Wu Ziwang
Gao Wenya
Zhang Lizhong
Abstract：Objective To evaluate the diagnostic and prognostic value of serum found in inflammatory zone 2(FIZZ2)in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with respiratory failure(RF).Methods One hundred and eighty-six cases of AECOPD patients with RF treated in the Emergency Department of Jiayuguan First People's Hospital from February 2020 to February 2023 were selected as the RF group and 186 cases of AECOPD patients without RF were selected as the non-AF group.Serum levels of FIZZ2,procalcitonin(PCT)and C-reactive protein(CRP)were determined by enzyme-related immunosorbent assay.Survival of patients with AECOPD combined with RF within 60 days was analyzed.According to survival,patients with AECOPD combined with RF were divided into death subgroup(56 cases)and survival subgroup(130 cases).Pearson correlation analysis was conducted to analyze the correlation between FIZZ2 and PCT and CRP.The factors affecting the prognosis of AECOPD patients with RF and the value of FIZZ2 in pre-dicting the prognosis of AECOPD patients with RF were analyzed.Results The levels of serum FIZZ2,PCT and CRP in RF group were higher than those in non-RF group(t/P=58.968/＜0.001,16260/＜0.001,10382/＜0.001).The levels of serum FIZZ2,PCT and CRP in death subgroup were higher than those in survival subgroup(t/P=5.164/＜0.001,4.141/＜0.001,12.354/＜0.001).Serum FIZZ2 levels were positively correlated with PCT and CRP levels in patients with AECOPD and RF(r/P=0.452/＜0.001,0.427/＜0.001).High PCT,high FIZZ2 and high APACHE Ⅱ scores were risk factors for poor prog-nosis in patients with AECOPD and RF[OR(95％CI)=1.680(1.111-2.541),1.921(1.147-3217),2.547(1278-5.078)].Ser-um FIZZ2,PCT,CRP and combined to predict the prognosis of patients with AECOPD combined RF AUC were 0.842,0.794,0.846,0.925,combined slightly better than their individual predictions(Z/P=3.465/0.001,2.399/0.016,2.194/0.028).Conclusion The increase of serum FIZZ2 level in patients with AECOPD combined with RF is associated with poor prognosis,and has a high value in predicting the prognosis of patients with AECOPD combined with RF.
Keywords：Acute exacerbation of chronic obstructive pulmonary diseaseRespiratory failureFound in inflamma-tory zone 2Inflammatory factorsPredictive value
Publication Date：2024-08-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 919-923 )