Diagnostic value of β-hCG,ALP,and CA125 Combined with abdominal color doppler Ultraso-nography in ectopic pregnancy patients

Gao Lin; Su Na; Wang Yuansheng; Lamuqunni; Mima; Suolangquzhen

doi:10.3969/j.issn.1671-6450.2024.07.017

Abstract：Objective To assess the serum expression levels of beta-human chorionic gonadotropin(beta-hCG),al-kaline phosphatase(ALP),and carcinoembryonic antigen 125(CA125)in patients with ectopic pregnancy(EP),and to inves-tigate the diagnostic value of transabdominal color Doppler ultrasound combined with beta-hCG,ALP,and CA125 for EP.Methods Seventy-nine EP patients who were admitted to the Gynecology Department of the Tibet Autonomous Region People's Hospital from June 2023 to April 2024 were selected as the case group,and 82 early pregnant women were selected as the control group.The levels of β-hCG,ALP,and CA125 in the serum of the two groups were measured,and the thick-ness of the endometrium and the amount of pelvic fluid were examined by transabdominal color Doppler ultrasound.The correlation between the serum β-hCG,ALP,and CA125 levels and the ultrasound parameters was analyzed by Pearson cor-relation analysis.The influencing factors of EP occurrence were analyzed by multivariate logistic regression analysis.The di-agnostic value of transabdominal color Doppler ultrasound combined with serum β-hCG,ALP,and CA125 for EP was ana-lyzed by receiver operating characteristic(ROC)curve.Results In the case group,the level of β-hCG,ALP were signifi-cantly lower than those in the control group(t=21.390,19.690,P＜0.001).Conversely,the levels of CA125 was notably higher(t=33390,P＜0.001).Furthermore,compared with the control group,the endometrial thickness was observed to be significantly thinner in the case group(t=14.440,P＜0.001).Additionally,a positive correlation was found between endome-trial thickness and serum β-hCG and ALP levels(r=0.685,0.632;P＜0.001),while a negative correlation was observed with CA125 level(r=-0.701;P＜0.001).Finally,multivariate logistic regression analysis showed that endometrial thickening,high serum β-hCG levels,and high ALP levels were protective factors for ectopic pregnancy[OR(95％CI)=0.937(0.896-0.972),0.873(0.804-0.948),0.077(0.034-0.097)],while high serum CA125 levels and increased pelvic fluid were risk fac-tors for ectopic pregnancy[OR(95％CI)=1232(1.161-1.307),2.955(1.887-4.626)].The thickness of the endometrial lin-ing,pelvic effusion,β-hCG,ALP,and CA125 demonstrated AUC values of 0.843,0.802,0.942,0.843,and 0.916 respectively.The combined AUC of these parameters was calculated to be 0.988 which indicated a superior predictive efficacy compared to individual parameters(Z=2.370,2.147,2.001,1.990,2.676,P=0.018,0.032,0.039,0.046,0.007).Conclusion EP patients have thin endometrial lining,increased pelvic fluid,low serumbeta-hCGlevels,low ALP levels,and high CA125 levels.Com-bining abdominal color ultrasound with serum beta-hCG,ALP,and CA125 levels can improve the diagnostic efficacy of EP.