Study on the expression level and predictive value of serum Salusin-α and Salusin-β in patients with coronary slow flow
Wang Yu
Zhao Ping
Jia Zhengpei
Chen Hua
Abstract：Objective To investigate the levels of serum Salusin-α and Salusin-β in patients with coronary slow flow(CSF)and their predictive value for CSF.Methods Clinical data of 108 patients who underwent coronary angiography(CAG)examination in the Department of Cardiology,Inner Mongolia Autonomous Region People's Hospital from June 2019 to June 2022 and showed no obvious stenosis of the coronary artery were selected.According to the blood flow classifica-tion of the myocardial infarction thrombolysis test(TIMI),they were divided into CSF group(TIMI grade 2 and below,66 cases)and control group(TIMI grade 3,42 cases).Enzyme-linked immunosorbent assay was used to measure the serum levels of Salusin-α and Salusin-β.Pearson linear correlation analysis was used to analyze the correlation between serum Sa-lusin-α,Salusin-βlevels and clinicalindicators.Multivariate Logistic regression analysis was used to analyze the riskfactors for CSF.Receiver operating characteristic curve was used to analyze the predictive value of serum Salusin-α,Salusin-β and their combination for CSF.Results Serum Salusin-β,smoking history,serum uric acid,left anterior descending artery(LAD),left circumflex artery(LCX),right coronary artery(RCA)frame count and average frame count of three coronary ar-teries in CSF group were significantly higher than those in control group(χ2/t/P=16.702/＜0.001,7.013/0.008,7.917/＜0.001,12.074/＜0.001,9.344/＜0.001,13.627/＜0.001,10.476/＜0.001),while serum albumin and serum Salusin-α levels were lower than those of the control group(t/P=8.084/＜0.001,19.189/＜0.001).Serum Salusin-α was negatively correlated with serum uric acid,LAD frame count,LCX frame count,RCA frame count and average frame count(r/P=-0.708/＜0.001,-0.769/＜0.001,-0.662/＜0.001,-0.635/＜0.001,-0.708/＜0.001)and positively correlated with serum albumin(r/P=0.667/＜0.001).Serum Salusin-β was positively correlated with serum uric acid,LAD frame count,LCX frame count,RCA frame count and average frame count(r/P=0.748/＜0.001,0.676/＜0.001,0.753/＜0.001,0.642/＜0.001,0.776/＜0.001),and negatively correlated with serum albumin(r/P=-0.589/＜0.001).Smoking history and Salusin-βwere independent risk factors for CSF,while ser-um albumin and Salusin-α were protective factors[OR(95%CI)=1.464(1.146-1.870),1.536(0.928-2.548),0.819(0.710-0.942),0.715(0.582-0.878),P＜0.05].The AUC of serum Salusin-α,Salusin-β,and their combination for predicting CSF was 0.840,0.782,and 0.896,respectively,and the combination of the two was better than each of them alone(Z=4.561,4.103,P=0.005,＜0.001).Conclusion Serum Salusin-α is decreased and Salusin-β is increased in patients with CSF,which are related to the severity of CSF.The combination of serum Salusin-α and Salusin-β has a high predictive value for CSF.
Keywords：Coronary slow flowSalusin-αSalusin-βPredictive value
Publication Date：2024-04-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 423-428 )