Thymopeptide combined with noninvasive ventilator-assisted ventilation in the treatment of COPD combined with re-spiratory failure
Duan Xiaokai
Sun Yongxiang
Yu Yong
Yu Xiaodan
Fan Shizhen
Chai Weifang
Abstract：Objective To explore the efficacy of thymopeptide combined with noninvasive ventilator-assisted ven-tilation in the treatment of patients with chronic obstructive pulmonary disease(COPD)combined with respiratory failure.Methods Eighty COPD patients with combined respiratory failure diagnosed and treated in the Department of Family Med-icine of Zhengzhou First People's Hospital from January 2020 to January 2023 were divided into 2 groups according to the different treatment plans,and non-invasive ventilator-assisted ventilation was included in the control group(n=40),and non-invasive ventilator-assisted ventilation was included in the control group(n=40).Patients treated with noninvasive ventilator-assisted ventilation combined with thymidine were included in the observation group(n=40).The clinical efficacy of the 2 groups and the partial pressure of blood oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),arterial oxygen saturation(SaO2),tumor necrosis factor-alpha(TNF-α),C-reactive protein(CRP),and interleukin-8(IL-8)before and after treatment were compared,Interleukin-18(IL-18),dyspnea(MRC score),symptoms(CAT score),and quality of life(SGRQ score).Results The total effective rate of in the observation group were 95.00%(38/40)higher than 77.50%(31/40)in the control group(χ2=5.165,P=0.023);after the treatment,the total effective rate of clinical treatment in the observation group was 95.00%(38/40)higher than that in the control group.0.023);after treatment,PaO2,SaO2,and IL-10 were higher in the observation group than in the control group,and PaCO2,TNF-α,CRP,and IL-18 were lower than in the control group(t= 4.169,4.173,8.624,6.572,7.294,10.320,6.024,P<0.001);after treatment,the MRC score,CAT score,and SGRQ score of the observation group were lower than those of the control group(t/P=2.715/0.008,5.440/<0.001,12.501/<0.001).Conclusion Thymopeptide combined with noninvasive ventilator-assisted ventilation is effective in COPD patients with respiratory fail-ure,which can regulate the process of immune-inflammatory reaction and restore blood gas indexes,thus improving clinical symptoms and promoting the quality of life.
Keywords：Chronic obstructive pulmonary diseaseRespiratory failureThymidineNoninvasive ventilatorAssis-ted ventilationTherapeutic effect
Publication Date：2024-03-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 308-312 )